Proteomics imaging and the kidney

Fulvio Magni, Maciej Lalowski, Veronica Mainini, Martina Marchetti-Deschmann, Clizia Chinello, Andrea Urbani, Marc Baumann

Research output: Contribution to journalArticle

Abstract

Matrix-assisted laser desorption/ionization (MALDI) and mass spectrometry (MS) imaging are advanced technologies capable of revealing the spatial distribution of different molecules - e.g., drugs and their metabolites, endogenous lipids and complex peptides/ proteins - directly in tissue specimens at the same time. Information obtained regarding tissues by MALDI profiling/imaging analysis can be correlated with other MS-based techniques, auxiliary imaging technologies and routine immunohistochemical stainings. In this review we describe the MALDI profiling/imaging technologies, providing examples of their application in kidney research.

Original languageEnglish
Pages (from-to)430-436
Number of pages7
JournalJournal of Nephrology
Volume26
Issue number3
DOIs
Publication statusPublished - May 2013

Keywords

  • Imaging mass spectrometry
  • Kidney
  • Tissue profiling

ASJC Scopus subject areas

  • Nephrology

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    Magni, F., Lalowski, M., Mainini, V., Marchetti-Deschmann, M., Chinello, C., Urbani, A., & Baumann, M. (2013). Proteomics imaging and the kidney. Journal of Nephrology, 26(3), 430-436. https://doi.org/10.5301/jn.5000243