Proteomics in celiac disease

V. De Re, M. P. Simula, L. Caggiari, A. Pavan, V. Canzonieri, R. Cannizzaro

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Proteomic technologies are used with increasing frequency in the scientific community. In this review we would like to highlight their use in celiac disease. The available techniques that include two-dimensional gel electrophoresis, mass spectrometry, antibody and tissue arrays, have been used to identify proteins or protein expression changes specific of gut tissue from patients with celiac disease. A number of studies have employed proteomic methodologies to look for diagnostic biomarkers in body fluids or to examine protein expression changes and posttranslational modifications during signaling. The fast technological development of technologies, along with the combination of classic techniques with proteomics, will lead to new discoveries which will consent a better understanding of the pathogenesis of celiac disease and its complications (i.e. refractory CD and cancer), and to possibily indicate targets for an early diagnosis of CD complications and for specific terapeutic approaches.

Original languageEnglish
Title of host publicationProteomics: Methods, Applications and Limitations
PublisherNova Science Publishers, Inc.
Pages1-14
Number of pages14
ISBN (Print)9781616686918
Publication statusPublished - 2011

Keywords

  • Lymphomas.
  • MALDI-TOF
  • Mass spectrometry
  • T-cell lymphoproliferations
  • Two-dimensional gel electrophoresis: DIGE

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    De Re, V., Simula, M. P., Caggiari, L., Pavan, A., Canzonieri, V., & Cannizzaro, R. (2011). Proteomics in celiac disease. In Proteomics: Methods, Applications and Limitations (pp. 1-14). Nova Science Publishers, Inc..