Proteomics in protein misfolding diseases

Monica Stoppini, Laura Obici, Francesca Lavatelli, Sofia Giorgetti, Loredana Marchese, Remigio Moratti, Vittorio Bellotti, Giampaolo Merlini

Research output: Contribution to journalArticle

Abstract

Protein misfolding and deposition as amyloid, with consequent tissue damage, plays a key role in the group of diseases generically termed amyloidoses. In the systemic forms, amyloid deposition is widespread and causes severe dysfunction of vital organs. Proteomic analysis, thanks to its versatility and the comprehensiveness of information obtained, is an ideal tool for the study of systemic amyloidoses. It has been successfully employed in the characterization of the circulating amyloidogenic precursors and the analysis of affected tissues, for the diagnostic identification of the fibril components and for characterizing disease-related changes in protein expression. We present the developments in the field of proteomics applied to systemic amyloidoses, and discuss the perspectives opened in the study of these diseases.

Original languageEnglish
Pages (from-to)627-635
Number of pages9
JournalClinical Chemistry and Laboratory Medicine
Volume47
Issue number6
DOIs
Publication statusPublished - Jun 1 2009

Keywords

  • Amyloidosis
  • Diagnosis
  • Pathogenesis
  • Protein misfolding diseases

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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