TY - JOUR
T1 - Proteomics technologies in endometriosis
AU - Ferrero, Simone
AU - Gillott, David John
AU - Remorgida, Valentino
AU - Ragni, Nicola
AU - Venturini, Pier Luigi
AU - Grudzinskas, Jurgis Gedis
PY - 2008/10
Y1 - 2008/10
N2 - Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics technologies have been used to research novel proteins with a potential etiological role in endometriosis, and to identify candidate serum markers for this condition. While some molecules identified by proteomics technologies may have a relevant role in the pathogenesis of endometriosis, the research of potential serum markers for this condition is still far from any clinical application. This review summarizes the state of the art and potential applications of proteomics in endometriosis research.
AB - Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics technologies have been used to research novel proteins with a potential etiological role in endometriosis, and to identify candidate serum markers for this condition. While some molecules identified by proteomics technologies may have a relevant role in the pathogenesis of endometriosis, the research of potential serum markers for this condition is still far from any clinical application. This review summarizes the state of the art and potential applications of proteomics in endometriosis research.
KW - 2D electrophoresis
KW - Diagnosis
KW - Endometriosis
KW - Pathogenesis
KW - Proteomics
KW - Serum
UR - http://www.scopus.com/inward/record.url?scp=54349094524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54349094524&partnerID=8YFLogxK
U2 - 10.1586/14789450.5.5.705
DO - 10.1586/14789450.5.5.705
M3 - Article
C2 - 18937560
AN - SCOPUS:54349094524
VL - 5
SP - 705
EP - 714
JO - Expert Review of Proteomics
JF - Expert Review of Proteomics
SN - 1478-9450
IS - 5
ER -