Proteomics technologies in endometriosis

Simone Ferrero; David John Gillott; Valentino Remorgida; Nicola Ragni; Pier Luigi Venturini; Jurgis Gedis Grudzinskas

doi:10.1586/14789450.5.5.705

Proteomics technologies in endometriosis

Simone Ferrero, David John Gillott, Valentino Remorgida, Nicola Ragni, Pier Luigi Venturini, Jurgis Gedis Grudzinskas

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics technologies have been used to research novel proteins with a potential etiological role in endometriosis, and to identify candidate serum markers for this condition. While some molecules identified by proteomics technologies may have a relevant role in the pathogenesis of endometriosis, the research of potential serum markers for this condition is still far from any clinical application. This review summarizes the state of the art and potential applications of proteomics in endometriosis research.

Original language	English
Pages (from-to)	705-714
Number of pages	10
Journal	Expert Review of Proteomics
Volume	5
Issue number	5
DOIs	https://doi.org/10.1586/14789450.5.5.705
Publication status	Published - Oct 2008

Keywords

2D electrophoresis
Diagnosis
Endometriosis
Pathogenesis
Proteomics
Serum

ASJC Scopus subject areas

Molecular Biology
Biochemistry

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10.1586/14789450.5.5.705

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abstract = "Endometriosis is a common disorder that is associated with infertility and pelvic pain. Diagnosis is based on the visualization of endometriotic lesions during surgery as no reliable serum marker is currently available. The etiology of endometriosis is largely unknown. Over the last 20 years, several proteomics technologies have been used to research novel proteins with a potential etiological role in endometriosis, and to identify candidate serum markers for this condition. While some molecules identified by proteomics technologies may have a relevant role in the pathogenesis of endometriosis, the research of potential serum markers for this condition is still far from any clinical application. This review summarizes the state of the art and potential applications of proteomics in endometriosis research.",

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