Abstract
Detection and typing of amyloid deposits in tissues are two crucial steps in the management of systemic amyloidoses. The presence of amyloid deposits is routinely evaluated through Congo red staining, whereas proteomics is now a mainstay in the identification of the deposited proteins. In article number 1700236, Winter et al. [Proteomics 2017, 17, Issue 22] describe a novel method based on MALDI-MS imaging coupled to ion mobility separation and peptide filtering, to detect the presence of amyloid in histology samples and to identify its composition, while preserving the spatial distribution of proteins in tissues.
| Original language | English |
|---|---|
| Journal | Proteomics |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2018 |
Fingerprint
Keywords
- Amyloid-associated proteins
- Amyloidosis
- Histology
- Mass spectrometry imaging
- Tissue slide
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
Cite this
Proteomics with Mass Spectrometry Imaging : Beyond Amyloid Typing. / Lavatelli, Francesca; Merlini, Giampaolo.
In: Proteomics, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proteomics with Mass Spectrometry Imaging
T2 - Beyond Amyloid Typing
AU - Lavatelli, Francesca
AU - Merlini, Giampaolo
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Detection and typing of amyloid deposits in tissues are two crucial steps in the management of systemic amyloidoses. The presence of amyloid deposits is routinely evaluated through Congo red staining, whereas proteomics is now a mainstay in the identification of the deposited proteins. In article number 1700236, Winter et al. [Proteomics 2017, 17, Issue 22] describe a novel method based on MALDI-MS imaging coupled to ion mobility separation and peptide filtering, to detect the presence of amyloid in histology samples and to identify its composition, while preserving the spatial distribution of proteins in tissues.
AB - Detection and typing of amyloid deposits in tissues are two crucial steps in the management of systemic amyloidoses. The presence of amyloid deposits is routinely evaluated through Congo red staining, whereas proteomics is now a mainstay in the identification of the deposited proteins. In article number 1700236, Winter et al. [Proteomics 2017, 17, Issue 22] describe a novel method based on MALDI-MS imaging coupled to ion mobility separation and peptide filtering, to detect the presence of amyloid in histology samples and to identify its composition, while preserving the spatial distribution of proteins in tissues.
KW - Amyloid-associated proteins
KW - Amyloidosis
KW - Histology
KW - Mass spectrometry imaging
KW - Tissue slide
UR - http://www.scopus.com/inward/record.url?scp=85043341142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85043341142&partnerID=8YFLogxK
U2 - 10.1002/pmic.201700353
DO - 10.1002/pmic.201700353
M3 - Article
AN - SCOPUS:85043341142
JO - Proteomics
JF - Proteomics
SN - 1615-9853
ER -