Proteomics with Mass Spectrometry Imaging: Beyond Amyloid Typing

Research output: Contribution to journalComment/debatepeer-review


Detection and typing of amyloid deposits in tissues are two crucial steps in the management of systemic amyloidoses. The presence of amyloid deposits is routinely evaluated through Congo red staining, whereas proteomics is now a mainstay in the identification of the deposited proteins. In article number 1700236, Winter et al. [Proteomics 2017, 17, Issue 22] describe a novel method based on MALDI–MS imaging coupled to ion mobility separation and peptide filtering, to detect the presence of amyloid in histology samples and to identify its composition, while preserving the spatial distribution of proteins in tissues.

Original languageEnglish
Article number1700353
JournalProteomics - Practical Proteomics
Issue number7
Publication statusPublished - Jan 1 2018


  • amyloid-associated proteins
  • Amyloidosis
  • histology
  • mass spectrometry imaging
  • tissue slide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


Dive into the research topics of 'Proteomics with Mass Spectrometry Imaging: Beyond Amyloid Typing'. Together they form a unique fingerprint.

Cite this