Proteomics with Mass Spectrometry Imaging

Beyond Amyloid Typing

Research output: Contribution to journalComment/debate

Abstract

Detection and typing of amyloid deposits in tissues are two crucial steps in the management of systemic amyloidoses. The presence of amyloid deposits is routinely evaluated through Congo red staining, whereas proteomics is now a mainstay in the identification of the deposited proteins. In article number 1700236, Winter et al. [Proteomics 2017, 17, Issue 22] describe a novel method based on MALDI–MS imaging coupled to ion mobility separation and peptide filtering, to detect the presence of amyloid in histology samples and to identify its composition, while preserving the spatial distribution of proteins in tissues.

Original languageEnglish
Article number1700353
JournalProteomics - Practical Proteomics
Volume18
Issue number7
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Amyloid Plaques
Amyloid
Proteomics
Mass spectrometry
Mass Spectrometry
Imaging techniques
Congo Red
Amyloidosis
Deposits
Tissue
Histology
Proteins
Ions
Staining and Labeling
Peptides
Spatial distribution
Chemical analysis

Keywords

  • amyloid-associated proteins
  • Amyloidosis
  • histology
  • mass spectrometry imaging
  • tissue slide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Proteomics with Mass Spectrometry Imaging : Beyond Amyloid Typing. / Lavatelli, Francesca; Merlini, Giampaolo.

In: Proteomics - Practical Proteomics, Vol. 18, No. 7, 1700353, 01.01.2018.

Research output: Contribution to journalComment/debate

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