Proteomineering: Has the mine been excavated?

Isabella Panfoli, Maurizio Bruschi, Silvia Ravera, Giovanni Candiano

Research output: Contribution to journalArticlepeer-review


The combinatorial peptide ligand library in association with mass spectrometry can greatly enhance the dynamic range of the analysis of low- and very low-abundance proteins constituting the vast majority of species in any sample. When compared with untreated samples, the increment in detection of low-abundance species appears to be at least fourfold. Recently, the combinatorial peptide ligand library has been challenged; however, it has been clearly demonstrated in the evaluated paper that the protocols for elution of the captured polypeptides make the difference. Therefore, the solid-phase ligand library made of hexapeptides remains a promising and unique tool for biomarker discovery.

Original languageEnglish
Pages (from-to)443-445
Number of pages3
JournalExpert Review of Proteomics
Issue number4
Publication statusPublished - Aug 2011


  • biomarkers
  • combinatorial peptide libraries
  • elution protocols
  • hexapeptide ligands
  • low-abundance proteome
  • mass spectrometry

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry


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