Prothrombin G20210A Mutation and Lower Extremity Peripheral Arterial Disease: A Systematic Review and Meta-analysis

F. Vazquez, M. Rodger, M. Carrier, G. Le Gal, J. L. Reny, F. Sofi, T. Mueller, S. Nagpal, P. Jetty, E. Gandara

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective/Background Despite being an important risk factor for venous thromboembolism, the role of the prothrombin G20210A mutation in patients with arterial disease remains unclear. The aim of this review was to evaluate the association of prothrombin G20210A and lower extremity peripheral arterial disease (PAD). Methods This was a systematic review and meta-analysis of case-control studies. A systematic review of electronic databases, including MEDLINE and Embase, was conducted to assess the prevalence of prothrombin G20210A in patients with lower extremity PAD. The main outcome was the prevalence of prothrombin G20210A in patients with lower extremity PAD. The random effects model odds ratio (OR) was used as the primary outcome measure. Results The initial electronic search identified 168 relevant abstracts of which five studies evaluating 1,524 cases of PAD and 1,553 controls were included. Prothrombin G20210A was found in 70 of 1,524 patients with lower extremity PAD and 44 of 1,553 of the controls (random effects OR 1.68, 95% confidence interval [CI] 0.8-3.2). In those with critical limb ischemia (CLI), the prevalence of prothrombin G20210A was 23 of 302 compared with 31 of 1,253 of the controls (OR 3.2, 95% CI 1.6-6.1). Conclusion Despite finding no significant association between lower extremity PAD and prothrombin G20210A, the meta-analysis suggests that the prevalence of prothrombin G20210A is significantly elevated in those with atherosclerotic occlusive disease of the lower extremities presenting with CLI. Well-designed prospective cohort studies evaluating the role of prothrombin G20210A as a predictor of disease progression or adverse vascular events are highly needed.

Original languageEnglish
Article number5760
Pages (from-to)232-240
Number of pages9
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume50
Issue number2
DOIs
Publication statusPublished - Aug 1 2015

Fingerprint

Peripheral Arterial Disease
Prothrombin
Meta-Analysis
Lower Extremity
Mutation
Odds Ratio
Ischemia
Extremities
Confidence Intervals
Venous Thromboembolism
MEDLINE
Blood Vessels
Disease Progression
Case-Control Studies
Cohort Studies
Outcome Assessment (Health Care)
Databases
Prospective Studies

Keywords

  • Peripheral vasculature
  • Prothrombin G20210A
  • Thrombin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Medicine(all)

Cite this

Prothrombin G20210A Mutation and Lower Extremity Peripheral Arterial Disease : A Systematic Review and Meta-analysis. / Vazquez, F.; Rodger, M.; Carrier, M.; Le Gal, G.; Reny, J. L.; Sofi, F.; Mueller, T.; Nagpal, S.; Jetty, P.; Gandara, E.

In: European Journal of Vascular and Endovascular Surgery, Vol. 50, No. 2, 5760, 01.08.2015, p. 232-240.

Research output: Contribution to journalArticle

Vazquez, F, Rodger, M, Carrier, M, Le Gal, G, Reny, JL, Sofi, F, Mueller, T, Nagpal, S, Jetty, P & Gandara, E 2015, 'Prothrombin G20210A Mutation and Lower Extremity Peripheral Arterial Disease: A Systematic Review and Meta-analysis', European Journal of Vascular and Endovascular Surgery, vol. 50, no. 2, 5760, pp. 232-240. https://doi.org/10.1016/j.ejvs.2015.04.033
Vazquez, F. ; Rodger, M. ; Carrier, M. ; Le Gal, G. ; Reny, J. L. ; Sofi, F. ; Mueller, T. ; Nagpal, S. ; Jetty, P. ; Gandara, E. / Prothrombin G20210A Mutation and Lower Extremity Peripheral Arterial Disease : A Systematic Review and Meta-analysis. In: European Journal of Vascular and Endovascular Surgery. 2015 ; Vol. 50, No. 2. pp. 232-240.
@article{6a1b87f89a8d432f84ba150cf1b77fd2,
title = "Prothrombin G20210A Mutation and Lower Extremity Peripheral Arterial Disease: A Systematic Review and Meta-analysis",
abstract = "Objective/Background Despite being an important risk factor for venous thromboembolism, the role of the prothrombin G20210A mutation in patients with arterial disease remains unclear. The aim of this review was to evaluate the association of prothrombin G20210A and lower extremity peripheral arterial disease (PAD). Methods This was a systematic review and meta-analysis of case-control studies. A systematic review of electronic databases, including MEDLINE and Embase, was conducted to assess the prevalence of prothrombin G20210A in patients with lower extremity PAD. The main outcome was the prevalence of prothrombin G20210A in patients with lower extremity PAD. The random effects model odds ratio (OR) was used as the primary outcome measure. Results The initial electronic search identified 168 relevant abstracts of which five studies evaluating 1,524 cases of PAD and 1,553 controls were included. Prothrombin G20210A was found in 70 of 1,524 patients with lower extremity PAD and 44 of 1,553 of the controls (random effects OR 1.68, 95{\%} confidence interval [CI] 0.8-3.2). In those with critical limb ischemia (CLI), the prevalence of prothrombin G20210A was 23 of 302 compared with 31 of 1,253 of the controls (OR 3.2, 95{\%} CI 1.6-6.1). Conclusion Despite finding no significant association between lower extremity PAD and prothrombin G20210A, the meta-analysis suggests that the prevalence of prothrombin G20210A is significantly elevated in those with atherosclerotic occlusive disease of the lower extremities presenting with CLI. Well-designed prospective cohort studies evaluating the role of prothrombin G20210A as a predictor of disease progression or adverse vascular events are highly needed.",
keywords = "Peripheral vasculature, Prothrombin G20210A, Thrombin",
author = "F. Vazquez and M. Rodger and M. Carrier and {Le Gal}, G. and Reny, {J. L.} and F. Sofi and T. Mueller and S. Nagpal and P. Jetty and E. Gandara",
year = "2015",
month = "8",
day = "1",
doi = "10.1016/j.ejvs.2015.04.033",
language = "English",
volume = "50",
pages = "232--240",
journal = "European Journal of Vascular and Endovascular Surgery",
issn = "1078-5884",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Prothrombin G20210A Mutation and Lower Extremity Peripheral Arterial Disease

T2 - A Systematic Review and Meta-analysis

AU - Vazquez, F.

AU - Rodger, M.

AU - Carrier, M.

AU - Le Gal, G.

AU - Reny, J. L.

AU - Sofi, F.

AU - Mueller, T.

AU - Nagpal, S.

AU - Jetty, P.

AU - Gandara, E.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objective/Background Despite being an important risk factor for venous thromboembolism, the role of the prothrombin G20210A mutation in patients with arterial disease remains unclear. The aim of this review was to evaluate the association of prothrombin G20210A and lower extremity peripheral arterial disease (PAD). Methods This was a systematic review and meta-analysis of case-control studies. A systematic review of electronic databases, including MEDLINE and Embase, was conducted to assess the prevalence of prothrombin G20210A in patients with lower extremity PAD. The main outcome was the prevalence of prothrombin G20210A in patients with lower extremity PAD. The random effects model odds ratio (OR) was used as the primary outcome measure. Results The initial electronic search identified 168 relevant abstracts of which five studies evaluating 1,524 cases of PAD and 1,553 controls were included. Prothrombin G20210A was found in 70 of 1,524 patients with lower extremity PAD and 44 of 1,553 of the controls (random effects OR 1.68, 95% confidence interval [CI] 0.8-3.2). In those with critical limb ischemia (CLI), the prevalence of prothrombin G20210A was 23 of 302 compared with 31 of 1,253 of the controls (OR 3.2, 95% CI 1.6-6.1). Conclusion Despite finding no significant association between lower extremity PAD and prothrombin G20210A, the meta-analysis suggests that the prevalence of prothrombin G20210A is significantly elevated in those with atherosclerotic occlusive disease of the lower extremities presenting with CLI. Well-designed prospective cohort studies evaluating the role of prothrombin G20210A as a predictor of disease progression or adverse vascular events are highly needed.

AB - Objective/Background Despite being an important risk factor for venous thromboembolism, the role of the prothrombin G20210A mutation in patients with arterial disease remains unclear. The aim of this review was to evaluate the association of prothrombin G20210A and lower extremity peripheral arterial disease (PAD). Methods This was a systematic review and meta-analysis of case-control studies. A systematic review of electronic databases, including MEDLINE and Embase, was conducted to assess the prevalence of prothrombin G20210A in patients with lower extremity PAD. The main outcome was the prevalence of prothrombin G20210A in patients with lower extremity PAD. The random effects model odds ratio (OR) was used as the primary outcome measure. Results The initial electronic search identified 168 relevant abstracts of which five studies evaluating 1,524 cases of PAD and 1,553 controls were included. Prothrombin G20210A was found in 70 of 1,524 patients with lower extremity PAD and 44 of 1,553 of the controls (random effects OR 1.68, 95% confidence interval [CI] 0.8-3.2). In those with critical limb ischemia (CLI), the prevalence of prothrombin G20210A was 23 of 302 compared with 31 of 1,253 of the controls (OR 3.2, 95% CI 1.6-6.1). Conclusion Despite finding no significant association between lower extremity PAD and prothrombin G20210A, the meta-analysis suggests that the prevalence of prothrombin G20210A is significantly elevated in those with atherosclerotic occlusive disease of the lower extremities presenting with CLI. Well-designed prospective cohort studies evaluating the role of prothrombin G20210A as a predictor of disease progression or adverse vascular events are highly needed.

KW - Peripheral vasculature

KW - Prothrombin G20210A

KW - Thrombin

UR - http://www.scopus.com/inward/record.url?scp=84938419049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938419049&partnerID=8YFLogxK

U2 - 10.1016/j.ejvs.2015.04.033

DO - 10.1016/j.ejvs.2015.04.033

M3 - Article

C2 - 26092622

AN - SCOPUS:84938419049

VL - 50

SP - 232

EP - 240

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

SN - 1078-5884

IS - 2

M1 - 5760

ER -