Prothrombotic genetic risk factors and the occurrence of gestational hypertension with or without proteinuria

Elvira Grandone, Maurizio Margaglione, Donatella Colaizzo, Giuseppe Cappucci, Natale Sciannamé, Sergio Montanaro, Dario Paladini, Pasquale Martinelli, Giovanni Di Minno

Research output: Contribution to journalArticlepeer-review


Gestational hypertension with or without proteinuria is a multifactorial disease in which the presence of a hypercoagulable state has been suggested. The prothrombin G20210A, the Factor V (FV) Leiden mutations, and the C677T 5-10 methylenetethrahydrofolate reductase (MTHFR) polymorphism were investigated in 140 women with gestational hypertension and in 216 normotensive women from Southern Italy. Nine controls (4.1%) and 16 cases (11.4%; OR 2.96, 95% CI: 1.27-6.91) carried the prothrombin A20210 allele. FV Leiden mutation was observed in 4 controls (1.8%) and 11 cases (7.9%; OR: 4.53, 95% CI: 1.41-14.53). The TT MTHFR genotype was found in 36 controls (16.6%) and 34 cases (24.4%; OR: 1.61, 95% CI: 0.96-2.74). The impact of potential confounding variables was evaluated using a logistic regression analysis. Nulliparity, Factor V Leiden and prothrombin A20210 carrier status resulted to be independent risk factors of having gestational hypertension with or without proteinuria. Imbalance of haemostasis, through prothrombotic genetic factors, may predispose to the occurrence of gestational hypertension.

Original languageEnglish
Pages (from-to)349-352
Number of pages4
JournalThrombosis and Haemostasis
Issue number3
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Hematology


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