Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR)

Enrico Baldi, Enrico Contri, Roman Burkart, Paola Borrelli, Ottavia Eleonora Ferraro, Michela Tonani, Amedeo Cutuli, Daniele Bertaia, Pasquale Iozzo, Caroline Tinguely, Daniel Lopez, Susi Boldarin, Claudio Deiuri, Sandrine Dénéréaz, Yves Dénéréaz, Michael Terrapon, Christian Tami, Cinzia Cereda, Alberto Somaschini, Stefano CornaraAndrea Cortegiani

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction Out-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality. The aim of this randomised trial is to compare three CPR protocols performed with different intentional interruptions with hands-only CPR. Methods and analysis This is a prospective randomised trial performed in eight training centres. Laypeople who passed a basic life support course will be randomised to one of the four CPR protocols in an 8 min simulated cardiac arrest scenario on a manikin: (1) 30 compressions and 2 s pause; (2) 50 compressions and 5 s pause; (3) 100 compressions and 10 s pause; (4) hands-only. The calculated sample size is 552 people. The primary outcome is the percentage of chest compression performed with correct depth evaluated by a computerised feedback system (Laerdal QCPR). Ethics and dissemination . Due to the nature of the study, we obtained a waiver from the Ethics Committee (IRCCS Policlinico San Matteo, Pavia, Italy). All participants will sign an informed consent form before randomisation. The results of this study will be published in peer-reviewed journal. The data collected will also be made available in a public data repository. trial registration number NCT02632500.

Original languageEnglish
Article number019723
JournalBMJ Open
Volume8
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Manikins
Cardiopulmonary Resuscitation
Hand
Heart Arrest
Thorax
Consent Forms
Out-of-Hospital Cardiac Arrest
Ethics Committees
Random Allocation
Developed Countries
Ethics
Sample Size
Italy
Ventilation
Cause of Death

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR). / Baldi, Enrico; Contri, Enrico; Burkart, Roman; Borrelli, Paola; Ferraro, Ottavia Eleonora; Tonani, Michela; Cutuli, Amedeo; Bertaia, Daniele; Iozzo, Pasquale; Tinguely, Caroline; Lopez, Daniel; Boldarin, Susi; Deiuri, Claudio; Dénéréaz, Sandrine; Dénéréaz, Yves; Terrapon, Michael; Tami, Christian; Cereda, Cinzia; Somaschini, Alberto; Cornara, Stefano; Cortegiani, Andrea.

In: BMJ Open, Vol. 8, No. 4, 019723, 01.01.2018.

Research output: Contribution to journalArticle

Baldi, E, Contri, E, Burkart, R, Borrelli, P, Ferraro, OE, Tonani, M, Cutuli, A, Bertaia, D, Iozzo, P, Tinguely, C, Lopez, D, Boldarin, S, Deiuri, C, Dénéréaz, S, Dénéréaz, Y, Terrapon, M, Tami, C, Cereda, C, Somaschini, A, Cornara, S & Cortegiani, A 2018, 'Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR)', BMJ Open, vol. 8, no. 4, 019723. https://doi.org/10.1136/bmjopen-2017-019723
Baldi, Enrico ; Contri, Enrico ; Burkart, Roman ; Borrelli, Paola ; Ferraro, Ottavia Eleonora ; Tonani, Michela ; Cutuli, Amedeo ; Bertaia, Daniele ; Iozzo, Pasquale ; Tinguely, Caroline ; Lopez, Daniel ; Boldarin, Susi ; Deiuri, Claudio ; Dénéréaz, Sandrine ; Dénéréaz, Yves ; Terrapon, Michael ; Tami, Christian ; Cereda, Cinzia ; Somaschini, Alberto ; Cornara, Stefano ; Cortegiani, Andrea. / Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR). In: BMJ Open. 2018 ; Vol. 8, No. 4.
@article{aa34f9447964464289320e00e4f6f8d8,
title = "Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR)",
abstract = "Introduction Out-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality. The aim of this randomised trial is to compare three CPR protocols performed with different intentional interruptions with hands-only CPR. Methods and analysis This is a prospective randomised trial performed in eight training centres. Laypeople who passed a basic life support course will be randomised to one of the four CPR protocols in an 8 min simulated cardiac arrest scenario on a manikin: (1) 30 compressions and 2 s pause; (2) 50 compressions and 5 s pause; (3) 100 compressions and 10 s pause; (4) hands-only. The calculated sample size is 552 people. The primary outcome is the percentage of chest compression performed with correct depth evaluated by a computerised feedback system (Laerdal QCPR). Ethics and dissemination . Due to the nature of the study, we obtained a waiver from the Ethics Committee (IRCCS Policlinico San Matteo, Pavia, Italy). All participants will sign an informed consent form before randomisation. The results of this study will be published in peer-reviewed journal. The data collected will also be made available in a public data repository. trial registration number NCT02632500.",
author = "Enrico Baldi and Enrico Contri and Roman Burkart and Paola Borrelli and Ferraro, {Ottavia Eleonora} and Michela Tonani and Amedeo Cutuli and Daniele Bertaia and Pasquale Iozzo and Caroline Tinguely and Daniel Lopez and Susi Boldarin and Claudio Deiuri and Sandrine D{\'e}n{\'e}r{\'e}az and Yves D{\'e}n{\'e}r{\'e}az and Michael Terrapon and Christian Tami and Cinzia Cereda and Alberto Somaschini and Stefano Cornara and Andrea Cortegiani",
year = "2018",
month = "1",
day = "1",
doi = "10.1136/bmjopen-2017-019723",
language = "English",
volume = "8",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "4",

}

TY - JOUR

T1 - Protocol of a multicenter international randomized controlled manikin study on different protocols of cardiopulmonary resuscitation for laypeople (MANI-CPR)

AU - Baldi, Enrico

AU - Contri, Enrico

AU - Burkart, Roman

AU - Borrelli, Paola

AU - Ferraro, Ottavia Eleonora

AU - Tonani, Michela

AU - Cutuli, Amedeo

AU - Bertaia, Daniele

AU - Iozzo, Pasquale

AU - Tinguely, Caroline

AU - Lopez, Daniel

AU - Boldarin, Susi

AU - Deiuri, Claudio

AU - Dénéréaz, Sandrine

AU - Dénéréaz, Yves

AU - Terrapon, Michael

AU - Tami, Christian

AU - Cereda, Cinzia

AU - Somaschini, Alberto

AU - Cornara, Stefano

AU - Cortegiani, Andrea

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction Out-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality. The aim of this randomised trial is to compare three CPR protocols performed with different intentional interruptions with hands-only CPR. Methods and analysis This is a prospective randomised trial performed in eight training centres. Laypeople who passed a basic life support course will be randomised to one of the four CPR protocols in an 8 min simulated cardiac arrest scenario on a manikin: (1) 30 compressions and 2 s pause; (2) 50 compressions and 5 s pause; (3) 100 compressions and 10 s pause; (4) hands-only. The calculated sample size is 552 people. The primary outcome is the percentage of chest compression performed with correct depth evaluated by a computerised feedback system (Laerdal QCPR). Ethics and dissemination . Due to the nature of the study, we obtained a waiver from the Ethics Committee (IRCCS Policlinico San Matteo, Pavia, Italy). All participants will sign an informed consent form before randomisation. The results of this study will be published in peer-reviewed journal. The data collected will also be made available in a public data repository. trial registration number NCT02632500.

AB - Introduction Out-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality. The aim of this randomised trial is to compare three CPR protocols performed with different intentional interruptions with hands-only CPR. Methods and analysis This is a prospective randomised trial performed in eight training centres. Laypeople who passed a basic life support course will be randomised to one of the four CPR protocols in an 8 min simulated cardiac arrest scenario on a manikin: (1) 30 compressions and 2 s pause; (2) 50 compressions and 5 s pause; (3) 100 compressions and 10 s pause; (4) hands-only. The calculated sample size is 552 people. The primary outcome is the percentage of chest compression performed with correct depth evaluated by a computerised feedback system (Laerdal QCPR). Ethics and dissemination . Due to the nature of the study, we obtained a waiver from the Ethics Committee (IRCCS Policlinico San Matteo, Pavia, Italy). All participants will sign an informed consent form before randomisation. The results of this study will be published in peer-reviewed journal. The data collected will also be made available in a public data repository. trial registration number NCT02632500.

UR - http://www.scopus.com/inward/record.url?scp=85045922630&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045922630&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2017-019723

DO - 10.1136/bmjopen-2017-019723

M3 - Article

AN - SCOPUS:85045922630

VL - 8

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 4

M1 - 019723

ER -