Proton beam radiotherapy: Report of the first ten patients treated at the "centro Nazionale di Adroterapia Oncologica (CNAO)" for skull base and spine tumours

Roberto Orecchia, Viviana Vitolo, Maria Rosaria Fiore, Piero Fossati, Alberto Iannalfi, Barbara Vischioni, Anurita Srivastava, Jeffrey Tuan, Mario Ciocca, Silvia Molinelli, Alfredo Mirandola, Gloria Vilches, Andrea Mairani, Barbara Tagaste, Marco Riboldi, Giulia Fontana, Guido Baroni, Sandro Rossi, Marco Krengli

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The Italian National Centre for Oncological Hadrontherapy (Centro Nazionale di Adroterapia Oncologica, CNAO), equipped with a proton and ion synchrotron, started clinical activity in September 2011. The clinical and technical characteristics of the first ten proton beam radiotherapy treatments are reported. Materials and methods: Ten patients, six males and four females (age range 27-73 years, median 55.5), were treated with proton beam radiotherapy. After one to two surgical procedures, seven patients received a histological diagnosis of chordoma (of the skull base in three cases, the cervical spine in one case and the sacrum in three cases) and three of low-grade chondrosarcoma (skull base). Prescribed doses were 74 GyE for chordoma and 70 GyE for chondrosarcoma at 2 GyE/fraction delivered 5 days per week. Results: Treatment was well tolerated without toxicity-related interruptions. The maximal acute toxicity was grade 2, with oropharyngeal mucositis, nausea and vomiting for the skull base tumours, and grade 2 dermatitis for the sacral tumours. After 6-12 months of follow-up, no patient developed tumour progression. Conclusions: The analysis of the first ten patients treated with proton therapy at CNAO showed that this treatment was feasible and safe. Currently, patient accrual into these as well as other approved protocols is continuing, and a longer follow-up period is needed to assess tumour control and late toxicity.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalRadiologia Medica
Volume119
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Chondrosarcoma
  • Chordoma
  • Hadrontherapy
  • Proton therapy
  • Skull base
  • Spine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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