TY - JOUR
T1 - Proton beam radiotherapy
T2 - Report of the first ten patients treated at the "centro Nazionale di Adroterapia Oncologica (CNAO)" for skull base and spine tumours
AU - Orecchia, Roberto
AU - Vitolo, Viviana
AU - Fiore, Maria Rosaria
AU - Fossati, Piero
AU - Iannalfi, Alberto
AU - Vischioni, Barbara
AU - Srivastava, Anurita
AU - Tuan, Jeffrey
AU - Ciocca, Mario
AU - Molinelli, Silvia
AU - Mirandola, Alfredo
AU - Vilches, Gloria
AU - Mairani, Andrea
AU - Tagaste, Barbara
AU - Riboldi, Marco
AU - Fontana, Giulia
AU - Baroni, Guido
AU - Rossi, Sandro
AU - Krengli, Marco
PY - 2014
Y1 - 2014
N2 - Purpose: The Italian National Centre for Oncological Hadrontherapy (Centro Nazionale di Adroterapia Oncologica, CNAO), equipped with a proton and ion synchrotron, started clinical activity in September 2011. The clinical and technical characteristics of the first ten proton beam radiotherapy treatments are reported. Materials and methods: Ten patients, six males and four females (age range 27-73 years, median 55.5), were treated with proton beam radiotherapy. After one to two surgical procedures, seven patients received a histological diagnosis of chordoma (of the skull base in three cases, the cervical spine in one case and the sacrum in three cases) and three of low-grade chondrosarcoma (skull base). Prescribed doses were 74 GyE for chordoma and 70 GyE for chondrosarcoma at 2 GyE/fraction delivered 5 days per week. Results: Treatment was well tolerated without toxicity-related interruptions. The maximal acute toxicity was grade 2, with oropharyngeal mucositis, nausea and vomiting for the skull base tumours, and grade 2 dermatitis for the sacral tumours. After 6-12 months of follow-up, no patient developed tumour progression. Conclusions: The analysis of the first ten patients treated with proton therapy at CNAO showed that this treatment was feasible and safe. Currently, patient accrual into these as well as other approved protocols is continuing, and a longer follow-up period is needed to assess tumour control and late toxicity.
AB - Purpose: The Italian National Centre for Oncological Hadrontherapy (Centro Nazionale di Adroterapia Oncologica, CNAO), equipped with a proton and ion synchrotron, started clinical activity in September 2011. The clinical and technical characteristics of the first ten proton beam radiotherapy treatments are reported. Materials and methods: Ten patients, six males and four females (age range 27-73 years, median 55.5), were treated with proton beam radiotherapy. After one to two surgical procedures, seven patients received a histological diagnosis of chordoma (of the skull base in three cases, the cervical spine in one case and the sacrum in three cases) and three of low-grade chondrosarcoma (skull base). Prescribed doses were 74 GyE for chordoma and 70 GyE for chondrosarcoma at 2 GyE/fraction delivered 5 days per week. Results: Treatment was well tolerated without toxicity-related interruptions. The maximal acute toxicity was grade 2, with oropharyngeal mucositis, nausea and vomiting for the skull base tumours, and grade 2 dermatitis for the sacral tumours. After 6-12 months of follow-up, no patient developed tumour progression. Conclusions: The analysis of the first ten patients treated with proton therapy at CNAO showed that this treatment was feasible and safe. Currently, patient accrual into these as well as other approved protocols is continuing, and a longer follow-up period is needed to assess tumour control and late toxicity.
KW - Chondrosarcoma
KW - Chordoma
KW - Hadrontherapy
KW - Proton therapy
KW - Skull base
KW - Spine
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U2 - 10.1007/s11547-013-0345-0
DO - 10.1007/s11547-013-0345-0
M3 - Article
C2 - 24337759
AN - SCOPUS:84898011387
VL - 119
SP - 277
EP - 282
JO - Radiologia Medica
JF - Radiologia Medica
SN - 0033-8362
IS - 4
ER -