Proton magnetic resonance spectroscopy and intracranial tumours: Clinical perspectives

Andrea Falini, Giovanna Calabrese, Daniela Origgi, Susanna Lipari, Fabio Triulzi, Marco Losa, Giuseppe Scotti

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Proton magnetic resonance spectroscopy ( 1H-MRS) was applied to characterize intracranial tumours of different hystological types. Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy. All tumours were characterized by reduced or absent N-acetylaspartate and increased signal from choline-containing compounds. Distinctive patterns were observed only for primitive brain neo-plasms; high-grade gliomas were differentiated from low-grade ones by higher levels of choline-containing compounds. The metabolic aspects of metastatic lesions were similar to high-grade gliomas. These results, together with the limitations of 1H-MRS and future applications are reviewed.

Original languageEnglish
Pages (from-to)706-714
Number of pages9
JournalJournal of Neurology
Volume243
Issue number10
DOIs
Publication statusPublished - 1996

Fingerprint

Choline
Glioma
Neoplasms
Brain Neoplasms
Radiotherapy
Drug Therapy
Brain
Proton Magnetic Resonance Spectroscopy
N-acetylaspartate

Keywords

  • Brain metabolism
  • Brain tumours
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Proton magnetic resonance spectroscopy and intracranial tumours : Clinical perspectives. / Falini, Andrea; Calabrese, Giovanna; Origgi, Daniela; Lipari, Susanna; Triulzi, Fabio; Losa, Marco; Scotti, Giuseppe.

In: Journal of Neurology, Vol. 243, No. 10, 1996, p. 706-714.

Research output: Contribution to journalArticle

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