Proton magnetic resonance spectroscopy and intracranial tumours: Clinical perspectives

Andrea Falini; Giovanna Calabrese; Daniela Origgi; Susanna Lipari; Fabio Triulzi; Marco Losa; Giuseppe Scotti

doi:10.1007/BF00873976

Proton magnetic resonance spectroscopy and intracranial tumours: Clinical perspectives

Andrea Falini, Giovanna Calabrese, Daniela Origgi, Susanna Lipari, Fabio Triulzi, Marco Losa, Giuseppe Scotti

Research output: Contribution to journal › Article › peer-review

Abstract

Proton magnetic resonance spectroscopy ( ¹H-MRS) was applied to characterize intracranial tumours of different hystological types. Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy. All tumours were characterized by reduced or absent N-acetylaspartate and increased signal from choline-containing compounds. Distinctive patterns were observed only for primitive brain neo-plasms; high-grade gliomas were differentiated from low-grade ones by higher levels of choline-containing compounds. The metabolic aspects of metastatic lesions were similar to high-grade gliomas. These results, together with the limitations of ¹H-MRS and future applications are reviewed.

Original language	English
Pages (from-to)	706-714
Number of pages	9
Journal	Journal of Neurology
Volume	243
Issue number	10
DOIs	https://doi.org/10.1007/BF00873976
Publication status	Published - 1996

Keywords

Brain metabolism
Brain tumours
Magnetic resonance spectroscopy

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1007/BF00873976

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AU - Falini, Andrea

AU - Calabrese, Giovanna

AU - Origgi, Daniela

AU - Lipari, Susanna

AU - Triulzi, Fabio

AU - Losa, Marco

AU - Scotti, Giuseppe

PY - 1996

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AB - Proton magnetic resonance spectroscopy ( 1H-MRS) was applied to characterize intracranial tumours of different hystological types. Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy. All tumours were characterized by reduced or absent N-acetylaspartate and increased signal from choline-containing compounds. Distinctive patterns were observed only for primitive brain neo-plasms; high-grade gliomas were differentiated from low-grade ones by higher levels of choline-containing compounds. The metabolic aspects of metastatic lesions were similar to high-grade gliomas. These results, together with the limitations of 1H-MRS and future applications are reviewed.

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