Abstract
Proton magnetic resonance spectroscopy ( 1H-MRS) was applied to characterize intracranial tumours of different hystological types. Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy. All tumours were characterized by reduced or absent N-acetylaspartate and increased signal from choline-containing compounds. Distinctive patterns were observed only for primitive brain neo-plasms; high-grade gliomas were differentiated from low-grade ones by higher levels of choline-containing compounds. The metabolic aspects of metastatic lesions were similar to high-grade gliomas. These results, together with the limitations of 1H-MRS and future applications are reviewed.
| Original language | English |
|---|---|
| Pages (from-to) | 706-714 |
| Number of pages | 9 |
| Journal | Journal of Neurology |
| Volume | 243 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1996 |
Fingerprint
Keywords
- Brain metabolism
- Brain tumours
- Magnetic resonance spectroscopy
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Proton magnetic resonance spectroscopy and intracranial tumours : Clinical perspectives. / Falini, Andrea; Calabrese, Giovanna; Origgi, Daniela; Lipari, Susanna; Triulzi, Fabio; Losa, Marco; Scotti, Giuseppe.
In: Journal of Neurology, Vol. 243, No. 10, 1996, p. 706-714.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proton magnetic resonance spectroscopy and intracranial tumours
T2 - Clinical perspectives
AU - Falini, Andrea
AU - Calabrese, Giovanna
AU - Origgi, Daniela
AU - Lipari, Susanna
AU - Triulzi, Fabio
AU - Losa, Marco
AU - Scotti, Giuseppe
PY - 1996
Y1 - 1996
N2 - Proton magnetic resonance spectroscopy ( 1H-MRS) was applied to characterize intracranial tumours of different hystological types. Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy. All tumours were characterized by reduced or absent N-acetylaspartate and increased signal from choline-containing compounds. Distinctive patterns were observed only for primitive brain neo-plasms; high-grade gliomas were differentiated from low-grade ones by higher levels of choline-containing compounds. The metabolic aspects of metastatic lesions were similar to high-grade gliomas. These results, together with the limitations of 1H-MRS and future applications are reviewed.
AB - Proton magnetic resonance spectroscopy ( 1H-MRS) was applied to characterize intracranial tumours of different hystological types. Seventy patients with intracranial neoplasms were studied before receiving surgery, radiotherapy or chemotherapy. All tumours were characterized by reduced or absent N-acetylaspartate and increased signal from choline-containing compounds. Distinctive patterns were observed only for primitive brain neo-plasms; high-grade gliomas were differentiated from low-grade ones by higher levels of choline-containing compounds. The metabolic aspects of metastatic lesions were similar to high-grade gliomas. These results, together with the limitations of 1H-MRS and future applications are reviewed.
KW - Brain metabolism
KW - Brain tumours
KW - Magnetic resonance spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=0029852027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029852027&partnerID=8YFLogxK
U2 - 10.1007/BF00873976
DO - 10.1007/BF00873976
M3 - Article
C2 - 8923303
AN - SCOPUS:0029852027
VL - 243
SP - 706
EP - 714
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 10
ER -