We used Proton Magnetic Resonance Spectroscopy (HI-MRS) to evaluate a presumed cerebral subcortical heterotopin in a 2,7 year old infant, presenting clinically with psychomotor retardation and drug resistant epilepsy. MRI showed a complete heterotopin of the left hemisphere, agenesia of the corpus callosum and an asymmetric developed right hemisphere. Spectra were obtained with a SE sequence (TE = 135 msec.). In the right hemisphere, spared by the pathologic process, no metabolic abnormalities were observed. In the giant lesion two different metabolic patterns were detected. In the posterior area, showing a diffuse structural disorganization, there was a slight decrease of both N-Acetil aspartate (NAA) and Choline (Cho). NAA was quite normal, whereas Cho was similarly slighty reduced in the anterior part of the lesion, where a less pronounced disorganization of gray and white was observed. These results support the giant subcortical heterotopia hypothesis, where the Cho and NAA variations could be respectively due to a myelination process delay and to an alteration of normal neuronal function. In any case, the presence of neoplastic tissue can be excluded basing on spectral profiles.
|Number of pages||4|
|Journal||Rivista di Neuroradiologia|
|Publication status||Published - 1994|
ASJC Scopus subject areas
- Clinical Neurology
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology