Proton magnetic resonance spectroscopy of the brain in pediatric patients

Tommaso Scarabino, Teresa Popolizio, Alessandro Bertolino, Ugo Salvolini

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

H1-MRS is a non-invasive technique which provides different levels of information on brain tissue: the N-acetyl aspartate (NAA) is an indicator of neuronal development, the choline containing compound peak (Cho) provides information on myelination and on cell membrane turnover and gliosis, inositol (Ins) is considered a marker of neuronal degeneration. Lactate may be detected in presence of defective energy metabolism. In the perineonatal period, the brain is apt to be insulted by a variety of events including asphyxia, hypoxemia, hemorrhage, which may subsequently cause delay in development. It is clinically important to assess the degree of brain damage and to obtain the prognostic information in the neonatal and early infantile period. MRS has become available for clinical examinations of the brain during development and these tecniques can be used to document improvement or the progression towards irreversible damage.

Original languageEnglish
Pages (from-to)142-153
Number of pages12
JournalEuropean Journal of Radiology
Volume30
Issue number2
DOIs
Publication statusPublished - May 1999

Fingerprint

Pediatrics
Brain
Gliosis
Asphyxia
Inositol
Choline
Energy Metabolism
Lactic Acid
Cell Membrane
Hemorrhage
Proton Magnetic Resonance Spectroscopy
N-acetylaspartate
Hypoxia

Keywords

  • Magnetic resonance spectroscopy
  • Metabolic diseases
  • MRI
  • Pediatric diseases

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Proton magnetic resonance spectroscopy of the brain in pediatric patients. / Scarabino, Tommaso; Popolizio, Teresa; Bertolino, Alessandro; Salvolini, Ugo.

In: European Journal of Radiology, Vol. 30, No. 2, 05.1999, p. 142-153.

Research output: Contribution to journalArticle

Scarabino, Tommaso ; Popolizio, Teresa ; Bertolino, Alessandro ; Salvolini, Ugo. / Proton magnetic resonance spectroscopy of the brain in pediatric patients. In: European Journal of Radiology. 1999 ; Vol. 30, No. 2. pp. 142-153.
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