Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis

Luca Bertinotti, Marzia Mortilla, Maria Letizia Conforti, Nicola Colangelo, Francesca Nacci, Angela Del Rosso, Claudio Fonda, Roberto Casale, Marco Matucci-Cerinic, Alberto Pignone

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective. Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Proton magnetic resonance spectroscopy ( 1H-MRS) assesses in vivo cerebral metabolites. We investigated the biochemical modifications of the CNS in SSc. Methods. N-acetylaspartate/creatine ratio (NAA/Cr) and choline/creatine ratio (Cho/Cr) at right centrum semiovale (RCS) and at right basal ganglia (RBG) were evaluated by 1H-MRS in 12 patients with limited (lSSc) and 8 patients with diffuse SSc (dSSc) and 20 control subjects. Results. With 1H-MRS, a significant reduction of NAA/Cr ratio at RBG (p <0.02) and at RCS (p <0.002) was detected in SSc patients. Cho/Cr ratio was increased (p <0.02) in the RCS, but not in RBG. In patients with lSSc, a significant reduction of NAA/Cr was detected in RCS but not in RBG. Conclusion. Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc.

Original languageEnglish
Pages (from-to)546-551
Number of pages6
JournalJournal of Rheumatology
Volume33
Issue number3
Publication statusPublished - Mar 2006

Fingerprint

Creatine
Systemic Scleroderma
Basal Ganglia
Central Nervous System
Choline
Diffuse Scleroderma
Proton Magnetic Resonance Spectroscopy
N-acetylaspartate

Keywords

  • Central nervous system
  • Neurometabolic alterations
  • Proton magnetic resonance spectroscopy
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Bertinotti, L., Mortilla, M., Conforti, M. L., Colangelo, N., Nacci, F., Del Rosso, A., ... Pignone, A. (2006). Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis. Journal of Rheumatology, 33(3), 546-551.

Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis. / Bertinotti, Luca; Mortilla, Marzia; Conforti, Maria Letizia; Colangelo, Nicola; Nacci, Francesca; Del Rosso, Angela; Fonda, Claudio; Casale, Roberto; Matucci-Cerinic, Marco; Pignone, Alberto.

In: Journal of Rheumatology, Vol. 33, No. 3, 03.2006, p. 546-551.

Research output: Contribution to journalArticle

Bertinotti, L, Mortilla, M, Conforti, ML, Colangelo, N, Nacci, F, Del Rosso, A, Fonda, C, Casale, R, Matucci-Cerinic, M & Pignone, A 2006, 'Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis', Journal of Rheumatology, vol. 33, no. 3, pp. 546-551.
Bertinotti L, Mortilla M, Conforti ML, Colangelo N, Nacci F, Del Rosso A et al. Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis. Journal of Rheumatology. 2006 Mar;33(3):546-551.
Bertinotti, Luca ; Mortilla, Marzia ; Conforti, Maria Letizia ; Colangelo, Nicola ; Nacci, Francesca ; Del Rosso, Angela ; Fonda, Claudio ; Casale, Roberto ; Matucci-Cerinic, Marco ; Pignone, Alberto. / Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis. In: Journal of Rheumatology. 2006 ; Vol. 33, No. 3. pp. 546-551.
@article{33fee23c219248a58d7b15cb8bcec742,
title = "Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis",
abstract = "Objective. Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Proton magnetic resonance spectroscopy ( 1H-MRS) assesses in vivo cerebral metabolites. We investigated the biochemical modifications of the CNS in SSc. Methods. N-acetylaspartate/creatine ratio (NAA/Cr) and choline/creatine ratio (Cho/Cr) at right centrum semiovale (RCS) and at right basal ganglia (RBG) were evaluated by 1H-MRS in 12 patients with limited (lSSc) and 8 patients with diffuse SSc (dSSc) and 20 control subjects. Results. With 1H-MRS, a significant reduction of NAA/Cr ratio at RBG (p <0.02) and at RCS (p <0.002) was detected in SSc patients. Cho/Cr ratio was increased (p <0.02) in the RCS, but not in RBG. In patients with lSSc, a significant reduction of NAA/Cr was detected in RCS but not in RBG. Conclusion. Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc.",
keywords = "Central nervous system, Neurometabolic alterations, Proton magnetic resonance spectroscopy, Systemic sclerosis",
author = "Luca Bertinotti and Marzia Mortilla and Conforti, {Maria Letizia} and Nicola Colangelo and Francesca Nacci and {Del Rosso}, Angela and Claudio Fonda and Roberto Casale and Marco Matucci-Cerinic and Alberto Pignone",
year = "2006",
month = "3",
language = "English",
volume = "33",
pages = "546--551",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "3",

}

TY - JOUR

T1 - Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis

AU - Bertinotti, Luca

AU - Mortilla, Marzia

AU - Conforti, Maria Letizia

AU - Colangelo, Nicola

AU - Nacci, Francesca

AU - Del Rosso, Angela

AU - Fonda, Claudio

AU - Casale, Roberto

AU - Matucci-Cerinic, Marco

AU - Pignone, Alberto

PY - 2006/3

Y1 - 2006/3

N2 - Objective. Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Proton magnetic resonance spectroscopy ( 1H-MRS) assesses in vivo cerebral metabolites. We investigated the biochemical modifications of the CNS in SSc. Methods. N-acetylaspartate/creatine ratio (NAA/Cr) and choline/creatine ratio (Cho/Cr) at right centrum semiovale (RCS) and at right basal ganglia (RBG) were evaluated by 1H-MRS in 12 patients with limited (lSSc) and 8 patients with diffuse SSc (dSSc) and 20 control subjects. Results. With 1H-MRS, a significant reduction of NAA/Cr ratio at RBG (p <0.02) and at RCS (p <0.002) was detected in SSc patients. Cho/Cr ratio was increased (p <0.02) in the RCS, but not in RBG. In patients with lSSc, a significant reduction of NAA/Cr was detected in RCS but not in RBG. Conclusion. Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc.

AB - Objective. Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Proton magnetic resonance spectroscopy ( 1H-MRS) assesses in vivo cerebral metabolites. We investigated the biochemical modifications of the CNS in SSc. Methods. N-acetylaspartate/creatine ratio (NAA/Cr) and choline/creatine ratio (Cho/Cr) at right centrum semiovale (RCS) and at right basal ganglia (RBG) were evaluated by 1H-MRS in 12 patients with limited (lSSc) and 8 patients with diffuse SSc (dSSc) and 20 control subjects. Results. With 1H-MRS, a significant reduction of NAA/Cr ratio at RBG (p <0.02) and at RCS (p <0.002) was detected in SSc patients. Cho/Cr ratio was increased (p <0.02) in the RCS, but not in RBG. In patients with lSSc, a significant reduction of NAA/Cr was detected in RCS but not in RBG. Conclusion. Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc.

KW - Central nervous system

KW - Neurometabolic alterations

KW - Proton magnetic resonance spectroscopy

KW - Systemic sclerosis

UR - http://www.scopus.com/inward/record.url?scp=33644672477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644672477&partnerID=8YFLogxK

M3 - Article

C2 - 16511924

AN - SCOPUS:33644672477

VL - 33

SP - 546

EP - 551

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 3

ER -