Proton MR spectroscopy of the brain at 3 T: An update

Alfonso Di Costanzo, Francesca Trojsi, Michela Tosetti, Timo Schirmer, Silke M. Lechner, Teresa Popolizio, Tommaso Scarabino

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Proton magnetic resonance spectroscopy (1H-MRS) provides specific metabolic information not otherwise observable by any other imaging method. 1H-MRS of the brain at 3 T is a new tool in the modern neuroradiological armamentarium whose main advantages, with respect to the well-established and technologically advanced 1.5-T 1H-MRS, include a higher signal-to-noise ratio, with a consequent increase in spatial and temporal resolutions, and better spectral resolution. These advantages allow the acquisition of higher quality and more easily quantifiable spectra in smaller voxels and/or in shorter times, and increase the sensitivity in metabolite detection. However, these advantages may be hampered by intrinsic field-dependent technical issues, such as decreased T2 signal, chemical shift dispersion errors, J-modulation anomalies, increased magnetic susceptibility, eddy current artifacts, challenges in designing and obtaining appropriate radiofrequency coils, magnetic field instability and safety hazards. All these limitations have been tackled by manufacturers and researchers and have received one or more solutions. Furthermore, advanced 1H-MRS techniques, such as specific spectral editing, fast 1H-MRS imaging and diffusion tensor 1H-MRS imaging, have been successfully implemented at 3 T. However, easier and more robust implementations of these techniques are still needed before they can become more widely used and undertake most of the clinical and research 1H-MRS applications.

Original languageEnglish
Pages (from-to)1651-1662
Number of pages12
JournalEuropean Radiology
Volume17
Issue number7
DOIs
Publication statusPublished - Jul 2007

Fingerprint

Protons
Magnetic Resonance Spectroscopy
Brain
Diffusion Tensor Imaging
Proton Magnetic Resonance Spectroscopy
Signal-To-Noise Ratio
Magnetic Fields
Artifacts
Research Personnel
Safety
Research

Keywords

  • Brain
  • Diagnostic imaging
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Di Costanzo, A., Trojsi, F., Tosetti, M., Schirmer, T., Lechner, S. M., Popolizio, T., & Scarabino, T. (2007). Proton MR spectroscopy of the brain at 3 T: An update. European Radiology, 17(7), 1651-1662. https://doi.org/10.1007/s00330-006-0546-1

Proton MR spectroscopy of the brain at 3 T : An update. / Di Costanzo, Alfonso; Trojsi, Francesca; Tosetti, Michela; Schirmer, Timo; Lechner, Silke M.; Popolizio, Teresa; Scarabino, Tommaso.

In: European Radiology, Vol. 17, No. 7, 07.2007, p. 1651-1662.

Research output: Contribution to journalArticle

Di Costanzo, A, Trojsi, F, Tosetti, M, Schirmer, T, Lechner, SM, Popolizio, T & Scarabino, T 2007, 'Proton MR spectroscopy of the brain at 3 T: An update', European Radiology, vol. 17, no. 7, pp. 1651-1662. https://doi.org/10.1007/s00330-006-0546-1
Di Costanzo, Alfonso ; Trojsi, Francesca ; Tosetti, Michela ; Schirmer, Timo ; Lechner, Silke M. ; Popolizio, Teresa ; Scarabino, Tommaso. / Proton MR spectroscopy of the brain at 3 T : An update. In: European Radiology. 2007 ; Vol. 17, No. 7. pp. 1651-1662.
@article{652cfa61162a4c0cb712d8183c33f27b,
title = "Proton MR spectroscopy of the brain at 3 T: An update",
abstract = "Proton magnetic resonance spectroscopy (1H-MRS) provides specific metabolic information not otherwise observable by any other imaging method. 1H-MRS of the brain at 3 T is a new tool in the modern neuroradiological armamentarium whose main advantages, with respect to the well-established and technologically advanced 1.5-T 1H-MRS, include a higher signal-to-noise ratio, with a consequent increase in spatial and temporal resolutions, and better spectral resolution. These advantages allow the acquisition of higher quality and more easily quantifiable spectra in smaller voxels and/or in shorter times, and increase the sensitivity in metabolite detection. However, these advantages may be hampered by intrinsic field-dependent technical issues, such as decreased T2 signal, chemical shift dispersion errors, J-modulation anomalies, increased magnetic susceptibility, eddy current artifacts, challenges in designing and obtaining appropriate radiofrequency coils, magnetic field instability and safety hazards. All these limitations have been tackled by manufacturers and researchers and have received one or more solutions. Furthermore, advanced 1H-MRS techniques, such as specific spectral editing, fast 1H-MRS imaging and diffusion tensor 1H-MRS imaging, have been successfully implemented at 3 T. However, easier and more robust implementations of these techniques are still needed before they can become more widely used and undertake most of the clinical and research 1H-MRS applications.",
keywords = "Brain, Diagnostic imaging, Magnetic resonance spectroscopy",
author = "{Di Costanzo}, Alfonso and Francesca Trojsi and Michela Tosetti and Timo Schirmer and Lechner, {Silke M.} and Teresa Popolizio and Tommaso Scarabino",
year = "2007",
month = "7",
doi = "10.1007/s00330-006-0546-1",
language = "English",
volume = "17",
pages = "1651--1662",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "7",

}

TY - JOUR

T1 - Proton MR spectroscopy of the brain at 3 T

T2 - An update

AU - Di Costanzo, Alfonso

AU - Trojsi, Francesca

AU - Tosetti, Michela

AU - Schirmer, Timo

AU - Lechner, Silke M.

AU - Popolizio, Teresa

AU - Scarabino, Tommaso

PY - 2007/7

Y1 - 2007/7

N2 - Proton magnetic resonance spectroscopy (1H-MRS) provides specific metabolic information not otherwise observable by any other imaging method. 1H-MRS of the brain at 3 T is a new tool in the modern neuroradiological armamentarium whose main advantages, with respect to the well-established and technologically advanced 1.5-T 1H-MRS, include a higher signal-to-noise ratio, with a consequent increase in spatial and temporal resolutions, and better spectral resolution. These advantages allow the acquisition of higher quality and more easily quantifiable spectra in smaller voxels and/or in shorter times, and increase the sensitivity in metabolite detection. However, these advantages may be hampered by intrinsic field-dependent technical issues, such as decreased T2 signal, chemical shift dispersion errors, J-modulation anomalies, increased magnetic susceptibility, eddy current artifacts, challenges in designing and obtaining appropriate radiofrequency coils, magnetic field instability and safety hazards. All these limitations have been tackled by manufacturers and researchers and have received one or more solutions. Furthermore, advanced 1H-MRS techniques, such as specific spectral editing, fast 1H-MRS imaging and diffusion tensor 1H-MRS imaging, have been successfully implemented at 3 T. However, easier and more robust implementations of these techniques are still needed before they can become more widely used and undertake most of the clinical and research 1H-MRS applications.

AB - Proton magnetic resonance spectroscopy (1H-MRS) provides specific metabolic information not otherwise observable by any other imaging method. 1H-MRS of the brain at 3 T is a new tool in the modern neuroradiological armamentarium whose main advantages, with respect to the well-established and technologically advanced 1.5-T 1H-MRS, include a higher signal-to-noise ratio, with a consequent increase in spatial and temporal resolutions, and better spectral resolution. These advantages allow the acquisition of higher quality and more easily quantifiable spectra in smaller voxels and/or in shorter times, and increase the sensitivity in metabolite detection. However, these advantages may be hampered by intrinsic field-dependent technical issues, such as decreased T2 signal, chemical shift dispersion errors, J-modulation anomalies, increased magnetic susceptibility, eddy current artifacts, challenges in designing and obtaining appropriate radiofrequency coils, magnetic field instability and safety hazards. All these limitations have been tackled by manufacturers and researchers and have received one or more solutions. Furthermore, advanced 1H-MRS techniques, such as specific spectral editing, fast 1H-MRS imaging and diffusion tensor 1H-MRS imaging, have been successfully implemented at 3 T. However, easier and more robust implementations of these techniques are still needed before they can become more widely used and undertake most of the clinical and research 1H-MRS applications.

KW - Brain

KW - Diagnostic imaging

KW - Magnetic resonance spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=34250307123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250307123&partnerID=8YFLogxK

U2 - 10.1007/s00330-006-0546-1

DO - 10.1007/s00330-006-0546-1

M3 - Article

C2 - 17235536

AN - SCOPUS:34250307123

VL - 17

SP - 1651

EP - 1662

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 7

ER -