Spettroscopia protonica a risonanza magnetica del ponte e del cervelletto in una famiglia con atassia spinocerebellare tipo 1

Translated title of the contribution: Proton MR spectroscopy of the pons and cerebellum in a family with spinocerebellar ataxia type 1

M. Mascalchi, M. Tosetti, C. Tessa, R. Plasmati, M. C. Bianchi, F. Valzania, M. Frontali, C. Bartolozzi, C. A. Tassinari

Research output: Contribution to journalArticle

Abstract

Single voxel proton MR spectroscopy of the basis pontis showed significantly decreased N-acetyl-aspartate/creatine and choline/creatine ratios in two patients with spinocerebellar ataxia type 1 (SCA1) and two still asymptomatic SCA1 carriers compared to six unaffected family members. No lactate was found in any family member. A significant decrease of the N- acetyl-aspartate/creatine but not of the choline/creatine ratio was also observed in the deep cerebellar hemisphere of the four SCA1 carriers compared to the unaffected family members. The reduction of the N-acetyl- aspartate/creatine ratio in the basis pontis of SCA1 carriers is likely to reflect the neuronal loss typical of the olivopontocerebellar degeneration underlying SCA1 and might represent an early biochemical marker of the disease.

Original languageItalian
Pages (from-to)32-33
Number of pages2
JournalRivista di Neuroradiologia
Volume10
Issue numberSUPPL. 2
Publication statusPublished - Oct 1997

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Spinocerebellar Ataxias
Pons
Creatine
Cerebellum
Protons
Magnetic Resonance Spectroscopy
Choline
Olivopontocerebellar Atrophies
Lactic Acid
Biomarkers
N-acetylaspartate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

Cite this

Spettroscopia protonica a risonanza magnetica del ponte e del cervelletto in una famiglia con atassia spinocerebellare tipo 1. / Mascalchi, M.; Tosetti, M.; Tessa, C.; Plasmati, R.; Bianchi, M. C.; Valzania, F.; Frontali, M.; Bartolozzi, C.; Tassinari, C. A.

In: Rivista di Neuroradiologia, Vol. 10, No. SUPPL. 2, 10.1997, p. 32-33.

Research output: Contribution to journalArticle

Mascalchi, M, Tosetti, M, Tessa, C, Plasmati, R, Bianchi, MC, Valzania, F, Frontali, M, Bartolozzi, C & Tassinari, CA 1997, 'Spettroscopia protonica a risonanza magnetica del ponte e del cervelletto in una famiglia con atassia spinocerebellare tipo 1', Rivista di Neuroradiologia, vol. 10, no. SUPPL. 2, pp. 32-33.
Mascalchi, M. ; Tosetti, M. ; Tessa, C. ; Plasmati, R. ; Bianchi, M. C. ; Valzania, F. ; Frontali, M. ; Bartolozzi, C. ; Tassinari, C. A. / Spettroscopia protonica a risonanza magnetica del ponte e del cervelletto in una famiglia con atassia spinocerebellare tipo 1. In: Rivista di Neuroradiologia. 1997 ; Vol. 10, No. SUPPL. 2. pp. 32-33.
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