Proton pump inhibitors and functional decline in older adults discharged from acute care hospitals

Andrea Corsonello, Marcello Maggio, Sergio Fusco, Bakhita Adamo, Diana Amantea, Claudio Pedone, Sabrina Garasto, Gian Paolo Ceda, Francesco Corica, Fabrizia Lattanzio, Raffaele Antonelli Incalzi

Research output: Contribution to journalArticle

Abstract

Objectives To investigate the relationship between use of proton pump inhibitors (PPIs) and incident dependency in older adults discharged from acute care hospitals. Design Prospective observational study. Setting Eleven geriatric and internal medicine acute care wards located throughout Italy. Participants Individuals (mean age 79.2 ± 5.5) who were not completely dependent at the time of discharge from participating wards (N = 401). Measurements The outcome of interest was the loss of at least one basic activity of daily living (ADL) from discharge to the end of follow-up (12 months). The relationship between PPI use and functional decline was investigated using logistic regression analysis before and after propensity score matching. Results Use of PPIs was significantly associated with functional decline before (odds ratio (OR) = 1.75, 95% confidence interval (CI) = 1.17-2.60) and after propensity score matching (OR = 2.44; 95% CI = 1.36-4.41). Other predictors of functional decline were hypoalbuminemia (OR = 3.10, 95% CI = 1.36-7.10 before matching, OR = 2.81, 95% CI = 1.09-7.77 after matching) and cognitive impairment (OR = 4.08, 95% CI = 1.63-10.2 before matching, OR = 6.35, 95% CI = 1.70-24.0 after matching). Conclusion Use of PPIs is associated with functional decline during 12 months of follow-up in older adults discharged from acute care hospitals.

Original languageEnglish
Pages (from-to)1110-1115
Number of pages6
JournalJournal of the American Geriatrics Society
Volume62
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • activities of daily living
  • elderly
  • functional decline
  • hospital
  • proton pump inhibitors

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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    Corsonello, A., Maggio, M., Fusco, S., Adamo, B., Amantea, D., Pedone, C., Garasto, S., Ceda, G. P., Corica, F., Lattanzio, F., & Antonelli Incalzi, R. (2014). Proton pump inhibitors and functional decline in older adults discharged from acute care hospitals. Journal of the American Geriatrics Society, 62(6), 1110-1115. https://doi.org/10.1111/jgs.12826