Protooncogene expression in normal and tumor-infiltrating phagocytes

Barbara Bottazzi, Zhen Guo Chen, Nadia Polentarutti, Francesca Chiaffarino, Alberto Mantovani, Francesco Colotta

Research output: Contribution to journalArticlepeer-review

Abstract

Expression of cellular protooncogene was investigated in freshly isolated human leukocytes and in tumor-associated macrophages isolated from murine fibrosarcomas. Normal leukocytes express high levels of c-fos and c-raf-I transcripts. Expression of c-fos and c-raf-I in leukocytes differ in many respects; in particular, agents that stimulate leukocyte functions augment c-fos expression but have no effects on c-raf-I transcription. Tumor-associated macrophages constitutively express c-fos protooncogene at levels higher than peritoneal macrophages. Moreover, in contrast to what happens in peritoneal macrophages, tumor-associated macrophages do not respond to endotoxin with an increase in c-fos expression.

Original languageEnglish
Pages (from-to)311-313
Number of pages3
JournalImmunology Letters
Volume16
Issue number3-4
DOIs
Publication statusPublished - 1987

Keywords

  • c-fos
  • c-raf
  • Phagocyte
  • Protooncogene expression
  • Tumor-associated macrophage

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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