Proven isolation of the pulmonary vein antrum with or without left atrial posterior wall isolation in patients with persistent atrial fibrillation

Rong Bai, Luigi Di Biase, Prasant Mohanty, Chintan Trivedi, Antonio Dello Russo, Sakis Themistoclakis, Michela Casella, Pietro Santarelli, Gaetano Fassini, Pasquale Santangeli, Sanghamitra Mohanty, Antonio Rossillo, Gemma Pelargonio, Rodney Horton, Javier Sanchez, Joseph Gallinghouse, J. David Burkhardt, Chang Sheng Ma, Claudio Tondo, Andrea Natale

Research output: Contribution to journalArticle

Abstract

Background It is unclear whether isolation of the left atrial posterior wall (LAPW) offers additional benefits over pulmonary vein antrum isolation (PVAI) alone in patients with persistent atrial fibrillation (AF). Objective We sought to determine the impact of PVAI and LAPW isolation (PVAI+LAPW) versus PVAI alone on the outcome of ablation of persistent AF. Methods During the first procedure, PVAI was performed in 20 patients (group 1), whereas in 32 patients (group 2), PVAI was extended to the left atrial (LA) septum and coronary sinus (CS), and isolation of the LAPW was targeted (ePVAI+LAPW). Isolation of the superior vena cava was achieved in both groups. All patients, regardless of arrhythmia recurrence, underwent a second procedure 3 months after the first procedure. In patients with reconnection of pulmonary veins or LAPW, reisolation was performed, and a third procedure was performed 3 months later to verify isolation. Patients entered follow-up only after PVAI (group 1) or PVAI+LAPW (group 2) isolation was proven. Results At the 1-, 2-, and 3-year follow-up examinations, the rates of freedom from atrial tachyarrhythmia without use of an antiarrhythmic drug were 20%, 15%, and 10% in group 1 and 65%, 50%, and 40% in group 2, respectively (log-rank P

Original languageEnglish
Pages (from-to)132-140
Number of pages9
JournalHeart Rhythm
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Left atrial posterior wall
  • Pulmonary vein antrum isolation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Bai, R., Di Biase, L., Mohanty, P., Trivedi, C., Dello Russo, A., Themistoclakis, S., Casella, M., Santarelli, P., Fassini, G., Santangeli, P., Mohanty, S., Rossillo, A., Pelargonio, G., Horton, R., Sanchez, J., Gallinghouse, J., Burkhardt, J. D., Ma, C. S., Tondo, C., & Natale, A. (2016). Proven isolation of the pulmonary vein antrum with or without left atrial posterior wall isolation in patients with persistent atrial fibrillation. Heart Rhythm, 13(1), 132-140. https://doi.org/10.1016/j.hrthm.2015.08.019