Proviral DNA of Moloney leukemia virus: purification and visualization

A. M. Gianni; J. R. Hutton; D. Smotkin; R. A. Weinberg

Proviral DNA of Moloney leukemia virus: purification and visualization

A. M. Gianni, J. R. Hutton, D. Smotkin, R. A. Weinberg

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Closed circular proviral DNA of Moloney leukemia virus has been purified from a 10⁷ excess of cellular and mitochondrial DNA. The DNA can be visualized in the electron microscope and has the contour length of a molecule with a molecular weight of about 5.5 x 10⁶. Electron microscopic observation of a hybrid between viral RNA and this circular DNA confirms the viral origin of this molecule.

Original language	English
Pages (from-to)	569-571
Number of pages	3
Journal	Science
Volume	191
Issue number	4227
Publication status	Published - 1976

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title = "Proviral DNA of Moloney leukemia virus: purification and visualization",

abstract = "Closed circular proviral DNA of Moloney leukemia virus has been purified from a 107 excess of cellular and mitochondrial DNA. The DNA can be visualized in the electron microscope and has the contour length of a molecule with a molecular weight of about 5.5 x 106. Electron microscopic observation of a hybrid between viral RNA and this circular DNA confirms the viral origin of this molecule.",

author = "Gianni, {A. M.} and Hutton, {J. R.} and D. Smotkin and Weinberg, {R. A.}",

year = "1976",

language = "English",

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AU - Hutton, J. R.

AU - Smotkin, D.

AU - Weinberg, R. A.

PY - 1976

Y1 - 1976

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AB - Closed circular proviral DNA of Moloney leukemia virus has been purified from a 107 excess of cellular and mitochondrial DNA. The DNA can be visualized in the electron microscope and has the contour length of a molecule with a molecular weight of about 5.5 x 106. Electron microscopic observation of a hybrid between viral RNA and this circular DNA confirms the viral origin of this molecule.

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