Proviral DNA of Moloney leukemia virus: purification and visualization

A. M. Gianni, J. R. Hutton, D. Smotkin, R. A. Weinberg

Research output: Contribution to journalArticle

Abstract

Closed circular proviral DNA of Moloney leukemia virus has been purified from a 107 excess of cellular and mitochondrial DNA. The DNA can be visualized in the electron microscope and has the contour length of a molecule with a molecular weight of about 5.5 x 106. Electron microscopic observation of a hybrid between viral RNA and this circular DNA confirms the viral origin of this molecule.

Original languageEnglish
Pages (from-to)569-571
Number of pages3
JournalScience
Volume191
Issue number4227
Publication statusPublished - 1976

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Moloney murine leukemia virus
Circular DNA
Electrons
DNA
Viral RNA
Mitochondrial DNA
Molecular Weight

ASJC Scopus subject areas

  • General

Cite this

Gianni, A. M., Hutton, J. R., Smotkin, D., & Weinberg, R. A. (1976). Proviral DNA of Moloney leukemia virus: purification and visualization. Science, 191(4227), 569-571.

Proviral DNA of Moloney leukemia virus : purification and visualization. / Gianni, A. M.; Hutton, J. R.; Smotkin, D.; Weinberg, R. A.

In: Science, Vol. 191, No. 4227, 1976, p. 569-571.

Research output: Contribution to journalArticle

Gianni, AM, Hutton, JR, Smotkin, D & Weinberg, RA 1976, 'Proviral DNA of Moloney leukemia virus: purification and visualization', Science, vol. 191, no. 4227, pp. 569-571.
Gianni AM, Hutton JR, Smotkin D, Weinberg RA. Proviral DNA of Moloney leukemia virus: purification and visualization. Science. 1976;191(4227):569-571.
Gianni, A. M. ; Hutton, J. R. ; Smotkin, D. ; Weinberg, R. A. / Proviral DNA of Moloney leukemia virus : purification and visualization. In: Science. 1976 ; Vol. 191, No. 4227. pp. 569-571.
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