Proximal tubular function and hyperfiltration during amino acid infusion in man

A. Claris-Appiani, B. M. Assael, A. S. Tirelli, G. Cavanna, C. Corbetta, G. Marra

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The relations between renal hemodynamics (Inutest, CPAH) and sodium segmental handling (sodium distal delivery, distal reabsorption, and fractional excretion) were studied in 9 healthy adults infused with an isotonic amino acid solution and in 6 subjects infused with 0.9% saline for 3 h at 0.2 ml/min/kg. During all tests maximal water diuresis was induced and maintained to effect analysis of sodium segmental transport. Both types of infusion produced a similar expansion of extracellular volume (weight increase, hematocrit fall, suppressed plasma renin activity and plasma aldosterone). The amino acid infusion increased the glomerular filtration rate (GFR) and renal blood flow without modifying the filtration fraction. With saline no hemodynamic modifications were observed. The expansion with saline depressed proximal and distal sodium reabsorption whereas during amino acid infusion sodium distal delivery was unaltered and the significantly increased sodium fractional excretion was sustained only by depressed distal reabsorption. Therefore, in parallel with the GFR increase, closely dependent on renal vasodilatation, the well-known stimulation of sodium cotransport by amino acids is able to antagonize the effects of expansion on the proximal sodium reabsorption. An explanation of glomerular hyperfiltration based on a primary metabolic stimulation of the proximal tubular function is suggested.

Original languageEnglish
Pages (from-to)96-101
Number of pages6
JournalAmerican Journal of Nephrology
Volume8
Issue number2
Publication statusPublished - 1988

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Sodium
Amino Acids
Glomerular Filtration Rate
Hemodynamics
Kidney
Renal Circulation
Diuresis
Aldosterone
Hematocrit
Renin
Vasodilation
Weights and Measures
Water

ASJC Scopus subject areas

  • Nephrology

Cite this

Claris-Appiani, A., Assael, B. M., Tirelli, A. S., Cavanna, G., Corbetta, C., & Marra, G. (1988). Proximal tubular function and hyperfiltration during amino acid infusion in man. American Journal of Nephrology, 8(2), 96-101.

Proximal tubular function and hyperfiltration during amino acid infusion in man. / Claris-Appiani, A.; Assael, B. M.; Tirelli, A. S.; Cavanna, G.; Corbetta, C.; Marra, G.

In: American Journal of Nephrology, Vol. 8, No. 2, 1988, p. 96-101.

Research output: Contribution to journalArticle

Claris-Appiani, A, Assael, BM, Tirelli, AS, Cavanna, G, Corbetta, C & Marra, G 1988, 'Proximal tubular function and hyperfiltration during amino acid infusion in man', American Journal of Nephrology, vol. 8, no. 2, pp. 96-101.
Claris-Appiani A, Assael BM, Tirelli AS, Cavanna G, Corbetta C, Marra G. Proximal tubular function and hyperfiltration during amino acid infusion in man. American Journal of Nephrology. 1988;8(2):96-101.
Claris-Appiani, A. ; Assael, B. M. ; Tirelli, A. S. ; Cavanna, G. ; Corbetta, C. ; Marra, G. / Proximal tubular function and hyperfiltration during amino acid infusion in man. In: American Journal of Nephrology. 1988 ; Vol. 8, No. 2. pp. 96-101.
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