Proximity to overhead power lines and childhood leukaemia

an international pooled analysis

Aryana T Amoon, Catherine M Crespi, Anders Ahlbom, Megha Bhatnagar, Isabelle Bray, Kathryn J Bunch, Jacqueline Clavel, Maria Feychting, Denis Hémon, Christoffer Johansen, Christian Kreis, Carlotta Malagoli, Fabienne Marquant, Camilla Pedersen, Ole Raaschou-Nielsen, Martin Röösli, Ben D Spycher, Madhuri Sudan, John Swanson, Andrea Tittarelli & 6 others Deirdre M Tuck, Tore Tynes, Ximena Vergara, Marco Vinceti, Victor Wünsch-Filho, Leeka Kheifets

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Although studies have consistently found an association between childhood leukaemia risk and magnetic fields, the associations between childhood leukaemia and distance to overhead power lines have been inconsistent. We pooled data from multiple studies to assess the association with distance and evaluate whether it is due to magnetic fields or other factors associated with distance from lines.

METHODS: We present a pooled analysis combining individual-level data (29,049 cases and 68,231 controls) from 11 record-based studies.

RESULTS: There was no material association between childhood leukaemia and distance to nearest overhead power line of any voltage. Among children living < 50 m from 200 + kV power lines, the adjusted odds ratio for childhood leukaemia was 1.33 (95% CI: 0.92-1.93). The odds ratio was higher among children diagnosed before age 5 years. There was no association with calculated magnetic fields. Odds ratios remained unchanged with adjustment for potential confounders.

CONCLUSIONS: In this first comprehensive pooled analysis of childhood leukaemia and distance to power lines, we found a small and imprecise risk for residences < 50 m of 200 + kV lines that was not explained by high magnetic fields. Reasons for the increased risk, found in this and many other studies, remains to be elucidated.

Original languageEnglish
Pages (from-to)364-373
Number of pages10
JournalBritish Journal of Cancer
Volume119
Issue number3
DOIs
Publication statusPublished - Aug 2018

Fingerprint

Magnetic Fields
Leukemia
Odds Ratio

Cite this

Amoon, A. T., Crespi, C. M., Ahlbom, A., Bhatnagar, M., Bray, I., Bunch, K. J., ... Kheifets, L. (2018). Proximity to overhead power lines and childhood leukaemia: an international pooled analysis. British Journal of Cancer, 119(3), 364-373. https://doi.org/10.1038/s41416-018-0097-7

Proximity to overhead power lines and childhood leukaemia : an international pooled analysis. / Amoon, Aryana T; Crespi, Catherine M; Ahlbom, Anders; Bhatnagar, Megha; Bray, Isabelle; Bunch, Kathryn J; Clavel, Jacqueline; Feychting, Maria; Hémon, Denis; Johansen, Christoffer; Kreis, Christian; Malagoli, Carlotta; Marquant, Fabienne; Pedersen, Camilla; Raaschou-Nielsen, Ole; Röösli, Martin; Spycher, Ben D; Sudan, Madhuri; Swanson, John; Tittarelli, Andrea; Tuck, Deirdre M; Tynes, Tore; Vergara, Ximena; Vinceti, Marco; Wünsch-Filho, Victor; Kheifets, Leeka.

In: British Journal of Cancer, Vol. 119, No. 3, 08.2018, p. 364-373.

Research output: Contribution to journalArticle

Amoon, AT, Crespi, CM, Ahlbom, A, Bhatnagar, M, Bray, I, Bunch, KJ, Clavel, J, Feychting, M, Hémon, D, Johansen, C, Kreis, C, Malagoli, C, Marquant, F, Pedersen, C, Raaschou-Nielsen, O, Röösli, M, Spycher, BD, Sudan, M, Swanson, J, Tittarelli, A, Tuck, DM, Tynes, T, Vergara, X, Vinceti, M, Wünsch-Filho, V & Kheifets, L 2018, 'Proximity to overhead power lines and childhood leukaemia: an international pooled analysis', British Journal of Cancer, vol. 119, no. 3, pp. 364-373. https://doi.org/10.1038/s41416-018-0097-7
Amoon, Aryana T ; Crespi, Catherine M ; Ahlbom, Anders ; Bhatnagar, Megha ; Bray, Isabelle ; Bunch, Kathryn J ; Clavel, Jacqueline ; Feychting, Maria ; Hémon, Denis ; Johansen, Christoffer ; Kreis, Christian ; Malagoli, Carlotta ; Marquant, Fabienne ; Pedersen, Camilla ; Raaschou-Nielsen, Ole ; Röösli, Martin ; Spycher, Ben D ; Sudan, Madhuri ; Swanson, John ; Tittarelli, Andrea ; Tuck, Deirdre M ; Tynes, Tore ; Vergara, Ximena ; Vinceti, Marco ; Wünsch-Filho, Victor ; Kheifets, Leeka. / Proximity to overhead power lines and childhood leukaemia : an international pooled analysis. In: British Journal of Cancer. 2018 ; Vol. 119, No. 3. pp. 364-373.
@article{8085aa028b34430896ad33ca545a614c,
title = "Proximity to overhead power lines and childhood leukaemia: an international pooled analysis",
abstract = "BACKGROUND: Although studies have consistently found an association between childhood leukaemia risk and magnetic fields, the associations between childhood leukaemia and distance to overhead power lines have been inconsistent. We pooled data from multiple studies to assess the association with distance and evaluate whether it is due to magnetic fields or other factors associated with distance from lines.METHODS: We present a pooled analysis combining individual-level data (29,049 cases and 68,231 controls) from 11 record-based studies.RESULTS: There was no material association between childhood leukaemia and distance to nearest overhead power line of any voltage. Among children living < 50 m from 200 + kV power lines, the adjusted odds ratio for childhood leukaemia was 1.33 (95{\%} CI: 0.92-1.93). The odds ratio was higher among children diagnosed before age 5 years. There was no association with calculated magnetic fields. Odds ratios remained unchanged with adjustment for potential confounders.CONCLUSIONS: In this first comprehensive pooled analysis of childhood leukaemia and distance to power lines, we found a small and imprecise risk for residences < 50 m of 200 + kV lines that was not explained by high magnetic fields. Reasons for the increased risk, found in this and many other studies, remains to be elucidated.",
author = "Amoon, {Aryana T} and Crespi, {Catherine M} and Anders Ahlbom and Megha Bhatnagar and Isabelle Bray and Bunch, {Kathryn J} and Jacqueline Clavel and Maria Feychting and Denis H{\'e}mon and Christoffer Johansen and Christian Kreis and Carlotta Malagoli and Fabienne Marquant and Camilla Pedersen and Ole Raaschou-Nielsen and Martin R{\"o}{\"o}sli and Spycher, {Ben D} and Madhuri Sudan and John Swanson and Andrea Tittarelli and Tuck, {Deirdre M} and Tore Tynes and Ximena Vergara and Marco Vinceti and Victor W{\"u}nsch-Filho and Leeka Kheifets",
year = "2018",
month = "8",
doi = "10.1038/s41416-018-0097-7",
language = "English",
volume = "119",
pages = "364--373",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Proximity to overhead power lines and childhood leukaemia

T2 - an international pooled analysis

AU - Amoon, Aryana T

AU - Crespi, Catherine M

AU - Ahlbom, Anders

AU - Bhatnagar, Megha

AU - Bray, Isabelle

AU - Bunch, Kathryn J

AU - Clavel, Jacqueline

AU - Feychting, Maria

AU - Hémon, Denis

AU - Johansen, Christoffer

AU - Kreis, Christian

AU - Malagoli, Carlotta

AU - Marquant, Fabienne

AU - Pedersen, Camilla

AU - Raaschou-Nielsen, Ole

AU - Röösli, Martin

AU - Spycher, Ben D

AU - Sudan, Madhuri

AU - Swanson, John

AU - Tittarelli, Andrea

AU - Tuck, Deirdre M

AU - Tynes, Tore

AU - Vergara, Ximena

AU - Vinceti, Marco

AU - Wünsch-Filho, Victor

AU - Kheifets, Leeka

PY - 2018/8

Y1 - 2018/8

N2 - BACKGROUND: Although studies have consistently found an association between childhood leukaemia risk and magnetic fields, the associations between childhood leukaemia and distance to overhead power lines have been inconsistent. We pooled data from multiple studies to assess the association with distance and evaluate whether it is due to magnetic fields or other factors associated with distance from lines.METHODS: We present a pooled analysis combining individual-level data (29,049 cases and 68,231 controls) from 11 record-based studies.RESULTS: There was no material association between childhood leukaemia and distance to nearest overhead power line of any voltage. Among children living < 50 m from 200 + kV power lines, the adjusted odds ratio for childhood leukaemia was 1.33 (95% CI: 0.92-1.93). The odds ratio was higher among children diagnosed before age 5 years. There was no association with calculated magnetic fields. Odds ratios remained unchanged with adjustment for potential confounders.CONCLUSIONS: In this first comprehensive pooled analysis of childhood leukaemia and distance to power lines, we found a small and imprecise risk for residences < 50 m of 200 + kV lines that was not explained by high magnetic fields. Reasons for the increased risk, found in this and many other studies, remains to be elucidated.

AB - BACKGROUND: Although studies have consistently found an association between childhood leukaemia risk and magnetic fields, the associations between childhood leukaemia and distance to overhead power lines have been inconsistent. We pooled data from multiple studies to assess the association with distance and evaluate whether it is due to magnetic fields or other factors associated with distance from lines.METHODS: We present a pooled analysis combining individual-level data (29,049 cases and 68,231 controls) from 11 record-based studies.RESULTS: There was no material association between childhood leukaemia and distance to nearest overhead power line of any voltage. Among children living < 50 m from 200 + kV power lines, the adjusted odds ratio for childhood leukaemia was 1.33 (95% CI: 0.92-1.93). The odds ratio was higher among children diagnosed before age 5 years. There was no association with calculated magnetic fields. Odds ratios remained unchanged with adjustment for potential confounders.CONCLUSIONS: In this first comprehensive pooled analysis of childhood leukaemia and distance to power lines, we found a small and imprecise risk for residences < 50 m of 200 + kV lines that was not explained by high magnetic fields. Reasons for the increased risk, found in this and many other studies, remains to be elucidated.

U2 - 10.1038/s41416-018-0097-7

DO - 10.1038/s41416-018-0097-7

M3 - Article

VL - 119

SP - 364

EP - 373

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 3

ER -