Pru p 3-sensitised italian peach-allergic patients are less likely to develop severe symptoms when also presenting ige antibodies to pru p 1 and pru p 4

Elide A. Pastorello, Laura Farioli, Valerio Pravettoni, Joseph Scibilia, Ambra Mascheri, Linda Borgonovo, Marta Piantanida, Laura Primavesi, Chrysi Stafylaraki, Sara Pasqualetti, Jan Schroeder, Michele Nichelatti, Alessandro Marocchi

Research output: Contribution to journalArticle

Abstract

Background: The roles played by different peach allergens with respect to symptom severity have not been completely ascertained. We have evaluated the diagnostic efficacy of peach recombinant allergens ImmunoCAP compared to peach in the identification of subjects at an increased risk for severe reactions to peaches. Methods: 148 peach-allergic patients were divided based on their symptom severity into 2 groups: mild oral allergy syndrome (OAS) and severe OAS. Anti-rPru p 1, 3 and 4 IgE levels were measured. Statistical analyses were carried out using parametric and non-parametric tests. Results: anti-rPru p 1 and anti-rPru p 4 IgE levels were significantly higher in patients with mild OAS than in patients with severe OAS (p = 0.0001); in contrast, anti-rPru p 3 IgE levels were significantly higher in patients with severe OAS than in patients with mild OAS (p <0.00005). Moreover, we found that any unitary increase in anti-rPru p 1 IgE values corresponded to a 2.48% reduction in the odds of having severe OAS (p = 0.048), whereas any unitary increase in anti-rPru p 3 IgE values corresponded to a 9.02% increase in the probability of having severe OAS (p = 0.001). Unexpectedly, we found that patients positive to rPru p 3 as well as rPru p 1 and 4 demonstrated a significant reduction of the odds of developing severe symptoms than those positive to rPru p 3 alone. Anti-rPru p 3 IgE levels were a significantly better indicator than anti-peach IgE values (p = 0.016) of patients with the highest risk for severe OAS. A cutoff of 2.69 kUA/l for anti-rPru p 3 IgE values better discriminated peach-allergic patients at a higher risk for symptoms. Conclusions: Italian patients with positive anti-rPru p 1, 4 and 3 IgE levels seemed less likely to experience the clinical effects of high anti-rPru p 3 IgE values.

Original languageEnglish
Pages (from-to)362-372
Number of pages11
JournalInternational Archives of Allergy and Immunology
Volume156
Issue number4
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Anti-rBet v 1
  • Anti-rBet v 2
  • Anti-rPru p 1
  • Anti-rPru p 3
  • Anti-rPru p 4
  • Birch allergy
  • Oral allergy syndrome
  • Peach allergens
  • Peach allergy
  • Recombinant allergens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Pastorello, E. A., Farioli, L., Pravettoni, V., Scibilia, J., Mascheri, A., Borgonovo, L., Piantanida, M., Primavesi, L., Stafylaraki, C., Pasqualetti, S., Schroeder, J., Nichelatti, M., & Marocchi, A. (2011). Pru p 3-sensitised italian peach-allergic patients are less likely to develop severe symptoms when also presenting ige antibodies to pru p 1 and pru p 4. International Archives of Allergy and Immunology, 156(4), 362-372. https://doi.org/10.1159/000324440