Abstract

Background: Psoriasis (Ps) is a chronic systemic autoimmune disease associated with pruritus in 64–98% of patients. However, few modestly sized studies assess factors associated with psoriatic pruritus. Objective: To investigate factors associated with Ps pruritus intensity. Methods: Psoriasis patients 18 years or older seen in one of 155 centres in Italy between September 2005 and 2009 were identified from the Italian PsoCare registry. Patients without cutaneous psoriasis and those with missed information on pruritus were excluded. Results: We identified 10 802 patients, with a mean age 48.8 ± 14.3 years. Mild itch was present in 33.2% of patients, moderate in 34.4%, severe in 18.7% and very severe in 13.7%. Higher itch intensity was associated with female gender, lower educational attainment compared to university degree, pustular psoriasis, psoriasis on the head, face, palmoplantar areas, folds and genitalia, more severe disease, disease duration <15 years, and no or few prior systemic treatments. Limitations: Effects of specific medication on itch were not assessed. Conclusions: Pruritus should be evaluated during psoriasis visits, and physicians should be aware of patients at higher risk for itch. Further studies are needed to assess the effects of medications on itch, and establish therapy for psoriasis patients with persistent itch.

Original languageEnglish
Pages (from-to)1316-1324
Number of pages9
JournalJournal of the European Academy of Dermatology and Venereology
Volume33
Issue number7
DOIs
Publication statusPublished - Jul 1 2019

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Pruritus
Psoriasis
Genitalia
Italy
Autoimmune Diseases
Registries
Head
Physicians
Skin
Therapeutics

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Pruritus characteristics in a large Italian cohort of psoriatic patients. / Psocare Registry Network.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 33, No. 7, 01.07.2019, p. 1316-1324.

Research output: Contribution to journalArticle

@article{57ade5226cb14ba68ed952209d1c4efb,
title = "Pruritus characteristics in a large Italian cohort of psoriatic patients",
abstract = "Background: Psoriasis (Ps) is a chronic systemic autoimmune disease associated with pruritus in 64–98{\%} of patients. However, few modestly sized studies assess factors associated with psoriatic pruritus. Objective: To investigate factors associated with Ps pruritus intensity. Methods: Psoriasis patients 18 years or older seen in one of 155 centres in Italy between September 2005 and 2009 were identified from the Italian PsoCare registry. Patients without cutaneous psoriasis and those with missed information on pruritus were excluded. Results: We identified 10 802 patients, with a mean age 48.8 ± 14.3 years. Mild itch was present in 33.2{\%} of patients, moderate in 34.4{\%}, severe in 18.7{\%} and very severe in 13.7{\%}. Higher itch intensity was associated with female gender, lower educational attainment compared to university degree, pustular psoriasis, psoriasis on the head, face, palmoplantar areas, folds and genitalia, more severe disease, disease duration <15 years, and no or few prior systemic treatments. Limitations: Effects of specific medication on itch were not assessed. Conclusions: Pruritus should be evaluated during psoriasis visits, and physicians should be aware of patients at higher risk for itch. Further studies are needed to assess the effects of medications on itch, and establish therapy for psoriasis patients with persistent itch.",
author = "{Psocare Registry Network} and G. Damiani and L. Bernardini and G. Ricotti and A. Giacchetti and A. Castelli and Belli, {M. A.} and M. Reggiani and A. Patrizi and Rossi, {M. T.} and Musumeci, {M. L.} and M. Pettinato and D. Brunelli and M. Coppola and M. Ottaviani and M. Condello and E. Bertani and A. Parodi and A. Nigro and G. Ghigliotti and K. Peris and {Di Cesare}, A. and M. Congedo and M. Celli and M. Ceccarini and A. Cattaneo and C. Carrera and P. Martino and M. Monti and L. Mancini and F. Sacrini and Altomare, {G. F.} and A. Giannetti and A. Conti and M. Greco and C. Fiorentini and E. Rossi and D. Tosi and F. Ayala and G. Argenziano and F. Todaro and G. Borroni and R. Cananzi and V. Brazzelli and M. Pavesi and G. Albertini and {Di Lernia}, V. and M. Morri and {De Simone}, C. and M. D'Agostino and E. Berardesca and M. Ardigo and {De Felice}, C. and F. Riccardi and {Di Vito}, C. and M. Pellegrino and G. Castelli and M. Forte and {De Luca}, G. and C. Venturi and Bellazzi, {R. M.}",
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doi = "10.1111/jdv.15539",
language = "English",
volume = "33",
pages = "1316--1324",
journal = "Journal of the European Academy of Dermatology and Venereology",
issn = "0926-9959",
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TY - JOUR

T1 - Pruritus characteristics in a large Italian cohort of psoriatic patients

AU - Psocare Registry Network

AU - Damiani, G.

AU - Bernardini, L.

AU - Ricotti, G.

AU - Giacchetti, A.

AU - Castelli, A.

AU - Belli, M. A.

AU - Reggiani, M.

AU - Patrizi, A.

AU - Rossi, M. T.

AU - Musumeci, M. L.

AU - Pettinato, M.

AU - Brunelli, D.

AU - Coppola, M.

AU - Ottaviani, M.

AU - Condello, M.

AU - Bertani, E.

AU - Parodi, A.

AU - Nigro, A.

AU - Ghigliotti, G.

AU - Peris, K.

AU - Di Cesare, A.

AU - Congedo, M.

AU - Celli, M.

AU - Ceccarini, M.

AU - Cattaneo, A.

AU - Carrera, C.

AU - Martino, P.

AU - Monti, M.

AU - Mancini, L.

AU - Sacrini, F.

AU - Altomare, G. F.

AU - Giannetti, A.

AU - Conti, A.

AU - Greco, M.

AU - Fiorentini, C.

AU - Rossi, E.

AU - Tosi, D.

AU - Ayala, F.

AU - Argenziano, G.

AU - Todaro, F.

AU - Borroni, G.

AU - Cananzi, R.

AU - Brazzelli, V.

AU - Pavesi, M.

AU - Albertini, G.

AU - Di Lernia, V.

AU - Morri, M.

AU - De Simone, C.

AU - D'Agostino, M.

AU - Berardesca, E.

AU - Ardigo, M.

AU - De Felice, C.

AU - Riccardi, F.

AU - Di Vito, C.

AU - Pellegrino, M.

AU - Castelli, G.

AU - Forte, M.

AU - De Luca, G.

AU - Venturi, C.

AU - Bellazzi, R. M.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: Psoriasis (Ps) is a chronic systemic autoimmune disease associated with pruritus in 64–98% of patients. However, few modestly sized studies assess factors associated with psoriatic pruritus. Objective: To investigate factors associated with Ps pruritus intensity. Methods: Psoriasis patients 18 years or older seen in one of 155 centres in Italy between September 2005 and 2009 were identified from the Italian PsoCare registry. Patients without cutaneous psoriasis and those with missed information on pruritus were excluded. Results: We identified 10 802 patients, with a mean age 48.8 ± 14.3 years. Mild itch was present in 33.2% of patients, moderate in 34.4%, severe in 18.7% and very severe in 13.7%. Higher itch intensity was associated with female gender, lower educational attainment compared to university degree, pustular psoriasis, psoriasis on the head, face, palmoplantar areas, folds and genitalia, more severe disease, disease duration <15 years, and no or few prior systemic treatments. Limitations: Effects of specific medication on itch were not assessed. Conclusions: Pruritus should be evaluated during psoriasis visits, and physicians should be aware of patients at higher risk for itch. Further studies are needed to assess the effects of medications on itch, and establish therapy for psoriasis patients with persistent itch.

AB - Background: Psoriasis (Ps) is a chronic systemic autoimmune disease associated with pruritus in 64–98% of patients. However, few modestly sized studies assess factors associated with psoriatic pruritus. Objective: To investigate factors associated with Ps pruritus intensity. Methods: Psoriasis patients 18 years or older seen in one of 155 centres in Italy between September 2005 and 2009 were identified from the Italian PsoCare registry. Patients without cutaneous psoriasis and those with missed information on pruritus were excluded. Results: We identified 10 802 patients, with a mean age 48.8 ± 14.3 years. Mild itch was present in 33.2% of patients, moderate in 34.4%, severe in 18.7% and very severe in 13.7%. Higher itch intensity was associated with female gender, lower educational attainment compared to university degree, pustular psoriasis, psoriasis on the head, face, palmoplantar areas, folds and genitalia, more severe disease, disease duration <15 years, and no or few prior systemic treatments. Limitations: Effects of specific medication on itch were not assessed. Conclusions: Pruritus should be evaluated during psoriasis visits, and physicians should be aware of patients at higher risk for itch. Further studies are needed to assess the effects of medications on itch, and establish therapy for psoriasis patients with persistent itch.

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U2 - 10.1111/jdv.15539

DO - 10.1111/jdv.15539

M3 - Article

AN - SCOPUS:85064493873

VL - 33

SP - 1316

EP - 1324

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

SN - 0926-9959

IS - 7

ER -