Abstract
Using a new immunoradiometric assay (ELSA pS2 Cis-France), a total of 200 cytosols obtained from primary breast tumors were examined for pS2 content, which is an estrogen-regulated protein actually studied as a marker of hormone sensitivity and favorable prognostic factor in breast cancer. In our patient group, the median pS2 value corresponding to 5.3 ng/mg of cytosolic proteins was used as cutoff. pS2 content was not related to menopause status, tumor size, or nodal involvement, whereas a positive correlation was found between pS2 and ER/PgR status. Moreover, the association of pS2 with steroid receptors seems to identify subgroups of patients better than ER/PgR alone.
Original language | English |
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Pages (from-to) | 101-110 |
Number of pages | 10 |
Journal | Cell Biophysics |
Volume | 22 |
Issue number | 1-3 |
DOIs | |
Publication status | Published - Jan 1993 |
Keywords
- Breast cancer
- hormone sensitivity
- pS2
ASJC Scopus subject areas
- Cell Biology
- Biophysics