Pseudoangiosarcomatous features in medullary carcinoma of the thyroid. Report of two cases

M. Papotti, A. Sapino, G. Abbona, N. Palestini, G. Bussolati

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Two cases of medullary carcinoma of the thyroid showing an angiosarcomatous pattern of growth are reported. Extensive hemorrhagic areas, strongly suggestive of a vascular tumor, characterized the gross appearance of case 1. Microscopically, pseudovascular spaces lined by elongated cells or containing nests of clear polygonal cells intermingled with red blood cells were a prominent feature in both cases. Calcitonin immunostaining was present in all neoplastic cells, both those in clear cell nests and the flat ones lining the pseudovascular spaces. A similar pattern was observed in cell block material obtained by fine-needle aspiration biopsy of case 2. Angiosarcoma-like medullary carcinoma of the thyroid patterns add to the long series of masquerades featuring medullary carcinoma of the thyroid and have to be considered in the differential diagnosis with hemangioendothelioma of the thyroid.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalInternational Journal of Surgical Pathology
Issue number1
Publication statusPublished - 1995


  • Angiosarcoma
  • Differential diagnosis
  • Medullary carcinoma
  • Pathology
  • Thyroid

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery


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