Abstract
Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the clinicopathologic characteristics of two new cases of pseudolymphomatous cutaneous angiosarcoma whose originality lies in the unusual setting from which they have arisen. In fact, the first case was an exceedingly lymphocyte-rich recurrence of a typical epithelioid cutaneous angiosarcoma whose primary lesion that was almost devoid of inflammatory infiltrate underwent surgical excision and radiotherapy while the second one was an unexpected histopathological finding associated with a basal cell carcinoma. Immunohistochemically, most of the lymphocytes expressed immunoreactivity for T-cell markers, while the neoplastic endothelial lymphatic cells expressed CD31 and CD34. D2-40 immunoreactivity was observed lining some channels and some neoplastic cells. In the first case a possible relationship between radiotherapy and the pseudolymphomatous reactive pattern is discussed while the second case has been considered as a rare example of collision tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 848-854 |
| Number of pages | 7 |
| Journal | Journal of Cutaneous Pathology |
| Volume | 40 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2013 |
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Keywords
- collision tumor
- cutaneous angiosarcoma
- vascular neoplasm
ASJC Scopus subject areas
- Dermatology
- Pathology and Forensic Medicine
- Histology
- Medicine(all)
Cite this
Pseudolymphomatous cutaneous angiosarcoma : A report of 2 new cases arising in an unusual setting. / Rongioletti, Franco; Albertini, Ann Flore; Fausti, Valentina; Cinotti, Elisa; Parodi, Aurora; Fraitag, Silvie.
In: Journal of Cutaneous Pathology, Vol. 40, No. 9, 09.2013, p. 848-854.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pseudolymphomatous cutaneous angiosarcoma
T2 - A report of 2 new cases arising in an unusual setting
AU - Rongioletti, Franco
AU - Albertini, Ann Flore
AU - Fausti, Valentina
AU - Cinotti, Elisa
AU - Parodi, Aurora
AU - Fraitag, Silvie
PY - 2013/9
Y1 - 2013/9
N2 - Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the clinicopathologic characteristics of two new cases of pseudolymphomatous cutaneous angiosarcoma whose originality lies in the unusual setting from which they have arisen. In fact, the first case was an exceedingly lymphocyte-rich recurrence of a typical epithelioid cutaneous angiosarcoma whose primary lesion that was almost devoid of inflammatory infiltrate underwent surgical excision and radiotherapy while the second one was an unexpected histopathological finding associated with a basal cell carcinoma. Immunohistochemically, most of the lymphocytes expressed immunoreactivity for T-cell markers, while the neoplastic endothelial lymphatic cells expressed CD31 and CD34. D2-40 immunoreactivity was observed lining some channels and some neoplastic cells. In the first case a possible relationship between radiotherapy and the pseudolymphomatous reactive pattern is discussed while the second case has been considered as a rare example of collision tumor.
AB - Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the clinicopathologic characteristics of two new cases of pseudolymphomatous cutaneous angiosarcoma whose originality lies in the unusual setting from which they have arisen. In fact, the first case was an exceedingly lymphocyte-rich recurrence of a typical epithelioid cutaneous angiosarcoma whose primary lesion that was almost devoid of inflammatory infiltrate underwent surgical excision and radiotherapy while the second one was an unexpected histopathological finding associated with a basal cell carcinoma. Immunohistochemically, most of the lymphocytes expressed immunoreactivity for T-cell markers, while the neoplastic endothelial lymphatic cells expressed CD31 and CD34. D2-40 immunoreactivity was observed lining some channels and some neoplastic cells. In the first case a possible relationship between radiotherapy and the pseudolymphomatous reactive pattern is discussed while the second case has been considered as a rare example of collision tumor.
KW - collision tumor
KW - cutaneous angiosarcoma
KW - vascular neoplasm
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UR - http://www.scopus.com/inward/citedby.url?scp=84883054608&partnerID=8YFLogxK
U2 - 10.1111/cup.12166
DO - 10.1111/cup.12166
M3 - Article
C2 - 23639118
AN - SCOPUS:84883054608
VL - 40
SP - 848
EP - 854
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
SN - 0303-6987
IS - 9
ER -