Pseudolymphomatous cutaneous angiosarcoma: A report of 2 new cases arising in an unusual setting

Franco Rongioletti, Ann Flore Albertini, Valentina Fausti, Elisa Cinotti, Aurora Parodi, Silvie Fraitag

Research output: Contribution to journalArticle

Abstract

Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the clinicopathologic characteristics of two new cases of pseudolymphomatous cutaneous angiosarcoma whose originality lies in the unusual setting from which they have arisen. In fact, the first case was an exceedingly lymphocyte-rich recurrence of a typical epithelioid cutaneous angiosarcoma whose primary lesion that was almost devoid of inflammatory infiltrate underwent surgical excision and radiotherapy while the second one was an unexpected histopathological finding associated with a basal cell carcinoma. Immunohistochemically, most of the lymphocytes expressed immunoreactivity for T-cell markers, while the neoplastic endothelial lymphatic cells expressed CD31 and CD34. D2-40 immunoreactivity was observed lining some channels and some neoplastic cells. In the first case a possible relationship between radiotherapy and the pseudolymphomatous reactive pattern is discussed while the second case has been considered as a rare example of collision tumor.

Original languageEnglish
Pages (from-to)848-854
Number of pages7
JournalJournal of Cutaneous Pathology
Volume40
Issue number9
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Hemangiosarcoma
Skin
Radiotherapy
Lymphocytes
Basal Cell Carcinoma
Masks
Blood Vessels
Endothelial Cells
T-Lymphocytes
Recurrence
Neoplasms

Keywords

  • collision tumor
  • cutaneous angiosarcoma
  • vascular neoplasm

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine
  • Histology
  • Medicine(all)

Cite this

Pseudolymphomatous cutaneous angiosarcoma : A report of 2 new cases arising in an unusual setting. / Rongioletti, Franco; Albertini, Ann Flore; Fausti, Valentina; Cinotti, Elisa; Parodi, Aurora; Fraitag, Silvie.

In: Journal of Cutaneous Pathology, Vol. 40, No. 9, 09.2013, p. 848-854.

Research output: Contribution to journalArticle

Rongioletti, Franco ; Albertini, Ann Flore ; Fausti, Valentina ; Cinotti, Elisa ; Parodi, Aurora ; Fraitag, Silvie. / Pseudolymphomatous cutaneous angiosarcoma : A report of 2 new cases arising in an unusual setting. In: Journal of Cutaneous Pathology. 2013 ; Vol. 40, No. 9. pp. 848-854.
@article{5e8574668158433aa4378a36376f6692,
title = "Pseudolymphomatous cutaneous angiosarcoma: A report of 2 new cases arising in an unusual setting",
abstract = "Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the clinicopathologic characteristics of two new cases of pseudolymphomatous cutaneous angiosarcoma whose originality lies in the unusual setting from which they have arisen. In fact, the first case was an exceedingly lymphocyte-rich recurrence of a typical epithelioid cutaneous angiosarcoma whose primary lesion that was almost devoid of inflammatory infiltrate underwent surgical excision and radiotherapy while the second one was an unexpected histopathological finding associated with a basal cell carcinoma. Immunohistochemically, most of the lymphocytes expressed immunoreactivity for T-cell markers, while the neoplastic endothelial lymphatic cells expressed CD31 and CD34. D2-40 immunoreactivity was observed lining some channels and some neoplastic cells. In the first case a possible relationship between radiotherapy and the pseudolymphomatous reactive pattern is discussed while the second case has been considered as a rare example of collision tumor.",
keywords = "collision tumor, cutaneous angiosarcoma, vascular neoplasm",
author = "Franco Rongioletti and Albertini, {Ann Flore} and Valentina Fausti and Elisa Cinotti and Aurora Parodi and Silvie Fraitag",
year = "2013",
month = "9",
doi = "10.1111/cup.12166",
language = "English",
volume = "40",
pages = "848--854",
journal = "Journal of Cutaneous Pathology",
issn = "0303-6987",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Pseudolymphomatous cutaneous angiosarcoma

T2 - A report of 2 new cases arising in an unusual setting

AU - Rongioletti, Franco

AU - Albertini, Ann Flore

AU - Fausti, Valentina

AU - Cinotti, Elisa

AU - Parodi, Aurora

AU - Fraitag, Silvie

PY - 2013/9

Y1 - 2013/9

N2 - Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the clinicopathologic characteristics of two new cases of pseudolymphomatous cutaneous angiosarcoma whose originality lies in the unusual setting from which they have arisen. In fact, the first case was an exceedingly lymphocyte-rich recurrence of a typical epithelioid cutaneous angiosarcoma whose primary lesion that was almost devoid of inflammatory infiltrate underwent surgical excision and radiotherapy while the second one was an unexpected histopathological finding associated with a basal cell carcinoma. Immunohistochemically, most of the lymphocytes expressed immunoreactivity for T-cell markers, while the neoplastic endothelial lymphatic cells expressed CD31 and CD34. D2-40 immunoreactivity was observed lining some channels and some neoplastic cells. In the first case a possible relationship between radiotherapy and the pseudolymphomatous reactive pattern is discussed while the second case has been considered as a rare example of collision tumor.

AB - Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the clinicopathologic characteristics of two new cases of pseudolymphomatous cutaneous angiosarcoma whose originality lies in the unusual setting from which they have arisen. In fact, the first case was an exceedingly lymphocyte-rich recurrence of a typical epithelioid cutaneous angiosarcoma whose primary lesion that was almost devoid of inflammatory infiltrate underwent surgical excision and radiotherapy while the second one was an unexpected histopathological finding associated with a basal cell carcinoma. Immunohistochemically, most of the lymphocytes expressed immunoreactivity for T-cell markers, while the neoplastic endothelial lymphatic cells expressed CD31 and CD34. D2-40 immunoreactivity was observed lining some channels and some neoplastic cells. In the first case a possible relationship between radiotherapy and the pseudolymphomatous reactive pattern is discussed while the second case has been considered as a rare example of collision tumor.

KW - collision tumor

KW - cutaneous angiosarcoma

KW - vascular neoplasm

UR - http://www.scopus.com/inward/record.url?scp=84883054608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883054608&partnerID=8YFLogxK

U2 - 10.1111/cup.12166

DO - 10.1111/cup.12166

M3 - Article

C2 - 23639118

AN - SCOPUS:84883054608

VL - 40

SP - 848

EP - 854

JO - Journal of Cutaneous Pathology

JF - Journal of Cutaneous Pathology

SN - 0303-6987

IS - 9

ER -