Pseudomonas aeruginosa infection in cystic fibrosis caused by an epidemic metallo-β-lactamase-producing clone with a heterogeneous carbapenem resistance phenotype

S. Pollini, E. Fiscarelli, C. Mugnaioli, V. di Pilato, G. Ricciotti, A. S. Neri, G. M. Rossolini

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

An epidemic IMP-13 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa clone, causing infections and even large outbreaks in Italian critical care settings, was detected in a young cystic fibrosis patient. In this patient, the chronic infection was sustained by distinct clonal sub-populations of the MBL-producing P. aeruginosa clone, either susceptible or resistant to carbapenems. These findings underscore the importance of infection prevention practices in cystic fibrosis settings and pose an important diagnostic and therapeutic challenge.

Original languageEnglish
Pages (from-to)1272-1275
Number of pages4
JournalClinical Microbiology and Infection
Volume17
Issue number8
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Pseudomonas Infections
Carbapenems
Cystic Fibrosis
Pseudomonas aeruginosa
Clone Cells
Phenotype
Infection
Inosine Monophosphate
Critical Care
Disease Outbreaks
Population
Therapeutics

Keywords

  • Carbapenems
  • Cystic fibrosis
  • Epidemic clone
  • Metallo-β-lactamase
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Pseudomonas aeruginosa infection in cystic fibrosis caused by an epidemic metallo-β-lactamase-producing clone with a heterogeneous carbapenem resistance phenotype. / Pollini, S.; Fiscarelli, E.; Mugnaioli, C.; di Pilato, V.; Ricciotti, G.; Neri, A. S.; Rossolini, G. M.

In: Clinical Microbiology and Infection, Vol. 17, No. 8, 08.2011, p. 1272-1275.

Research output: Contribution to journalArticle

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