Pseudoxanthoma elasticum: A rare cause of gastrointestinal bleeding

Giancarlo Spinzi, Enrico Strocchi, Gianni Imperiali, Angelo Sangiovanni, Vittorio Terruzzi, Giorgio Minoli

Research output: Contribution to journalArticlepeer-review


Pseudoxanthoma elasticum (PXE) is a rare connective tissue disorder. The main clinical features of this condition are characteristic skin lesions, angioid streaks of the fundus oculi, and occlusive vascular disease. Gastric hemorrhage is a rare complication. A gastroscopic examination was performed on two patients with PXE who presented with upper gastrointestinal tract bleeding. The two patients had submucosal yellowish nodular lesions similar to the xanthoma-like skin lesions seen in the disease. We suggest that a diagnosis of PXE be considered for any patient with gastrointestinal hemorrhage, especially if routine clinical and endoscopic examination fail to reveal the cause, and if raised yellow plaque-like lesions are seen in the stomach by endoscopy.

Original languageEnglish
Pages (from-to)1631-1634
Number of pages4
JournalAmerican Journal of Gastroenterology
Issue number8
Publication statusPublished - Aug 1996

ASJC Scopus subject areas

  • Gastroenterology


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