PSIP1/LEDGF: A new gene likely involved in sensorineural progressive hearing loss

Giorgia Girotto, Déborah I. Scheffer, Anna Morgan, Diego Vozzi, Elisa Rubinato, Mariateresa Di Stazio, Enrico Muzzi, Stefano Pensiero, Anne B. Giersch, David P. Corey, Paolo Gasparini

Research output: Contribution to journalArticlepeer-review


Hereditary Hearing Loss (HHL) is an extremely heterogeneous disorder. Approximately 30 out of 80 known HHL genes are associated with autosomal dominant forms. Here, we identified PSIP1/LEDGF (isoform p75) as a novel strong candidate gene involved in dominant HHL. Using exome sequencing we found a frameshift deletion (c.1554-1555del leading to p.E518Dfs∗2) in an Italian pedigree affected by sensorineural mild-to-moderate HHL but also showing a variable eye phenotype (i.e. uveitis, optic neuropathy). This deletion led to a premature stop codon (p.T519X) with truncation of the last 12 amino acids. PSIP1 was recently described as a transcriptional co-activator regulated by miR-135b in vestibular hair cells of the mouse inner ear as well as a possible protector against photoreceptor degeneration. Here, we demonstrate that it is ubiquitously expressed in the mouse inner ear. The PSIP1 mutation is associated with a peculiar audiometric slope toward the high frequencies. These findings indicate that PSIP1 likely plays an important role in HHL.

Original languageEnglish
Article number18568
JournalScientific Reports
Publication statusPublished - Dec 22 2015

ASJC Scopus subject areas

  • General


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