Psoriasis: Comparison of immunological markers in patients with acute and remission phase

O. De Pità, M. Ruffelli, S. Cadoni, A. Frezzolini, G. F. Biava, R. Simom, V. Bottari, G. De Sanctis

Research output: Contribution to journalArticle

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Abstract

The immune system involvement in psoriasis has been documented by the presence of activated T-cells both in peripheral blood and in psoriatic skin lesions and by the intervention of cytokines in the inflammatory process. On this basis, we have undertaken a study in order to examine, in addition to activation markers such as CD25 and CD54 (ICAM-1) on peripheral blood mononuclear cells (PBMNCs) surface, serum levels of soluble interleukin (IL)-2 receptor (sIL-2R), soluble ICAM-1 (sICAM-1), soluble CD4 (sCD4), soluble CD8 (sCD8), β2-microglobulin and fibronectin (FN) in psoriatic patients analyzed both in acute and remission phase obtained by topical therapy alone. Our results show that PBMNCs expressing IL-2 receptor (CD25) were increased both in percentage and absolute number in respect to controls, and were not modified after remission. On the contrary, the significantly higher number of CD54 + lymphocytes evaluated in acute psoriasis, showed a reduction during the remission phase, even if the values persisted higher than controls. Serum levels of sIL-2R, sICAM-1, sCD4, sCD8 and β2-microglobulin were significantly higher than controls both in acute and remission phase; only FN levels were found to be lower, in patients evaluated both in acute psoriasis and after therapy, in respect to normal donors. On the whole, these results seem to indicate the persistence of both cellular and soluble activation markers even in psoriasis remission phase; in this light, we can suppose that topical therapy alone is not able to efficiently down-regulate activation mechanisms involved in the pathogenesis of the disease.

Original languageEnglish
Pages (from-to)118-124
Number of pages7
JournalJournal of Dermatological Science
Volume13
Issue number2
DOIs
Publication statusPublished - Nov 1996

Fingerprint

Interleukin-2 Receptors
Intercellular Adhesion Molecule-1
Psoriasis
Blood
Chemical activation
Fibronectins
Blood Cells
T-cells
Lymphocytes
Immune system
Interleukins
Skin
Lymphocyte Count
Serum
Cytokines
Immune System
Therapeutics
Down-Regulation
Tissue Donors
T-Lymphocytes

Keywords

  • Adhesion molecules
  • Immune system
  • Psoriasis
  • Soluble factors
  • Topical therapy

ASJC Scopus subject areas

  • Dermatology

Cite this

De Pità, O., Ruffelli, M., Cadoni, S., Frezzolini, A., Biava, G. F., Simom, R., ... De Sanctis, G. (1996). Psoriasis: Comparison of immunological markers in patients with acute and remission phase. Journal of Dermatological Science, 13(2), 118-124. https://doi.org/10.1016/S0923-1811(96)00517-8

Psoriasis : Comparison of immunological markers in patients with acute and remission phase. / De Pità, O.; Ruffelli, M.; Cadoni, S.; Frezzolini, A.; Biava, G. F.; Simom, R.; Bottari, V.; De Sanctis, G.

In: Journal of Dermatological Science, Vol. 13, No. 2, 11.1996, p. 118-124.

Research output: Contribution to journalArticle

De Pità, O, Ruffelli, M, Cadoni, S, Frezzolini, A, Biava, GF, Simom, R, Bottari, V & De Sanctis, G 1996, 'Psoriasis: Comparison of immunological markers in patients with acute and remission phase', Journal of Dermatological Science, vol. 13, no. 2, pp. 118-124. https://doi.org/10.1016/S0923-1811(96)00517-8
De Pità, O. ; Ruffelli, M. ; Cadoni, S. ; Frezzolini, A. ; Biava, G. F. ; Simom, R. ; Bottari, V. ; De Sanctis, G. / Psoriasis : Comparison of immunological markers in patients with acute and remission phase. In: Journal of Dermatological Science. 1996 ; Vol. 13, No. 2. pp. 118-124.
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AU - De Sanctis, G.

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