Psoriasis plaque test with confocal microscopy: Evaluation of different microscopic response pathways in NSAID and steroid treated lesions

Marco Ardigò, Marina Agozzino, Caterina Longo, Andrea Conti, Vito Di Lernia, Enzo Berardesca, Giovanni Pellacani

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Pathophysiology of psoriasis is complex and characterized by microscopic, specific changes. In vivo reflectance confocal microscopy (RCM) provides tissue and cell morphology information in non-invasive way, generating quasi-histologic resolution. Concerning plaque psoriasis, confocal criteria have been described disclosing high agreement between RCM and conventional histology. Objective: We sought to evaluate the in vivo microscopic changes in plaque psoriasis occurring during treatment with two distinct actives (aceclofenac and betamethason). Methods: A total of 32 patients with psoriasis were recruited. Two lesions from the same body area or symmetrical were evaluated at baseline and after 3-6 weeks by RCM. Results: Aceclofenac induced clinical improvement in 32% of patients after 3 weeks and in 76% after 6 weeks. With betamethason, at the end of the 3rd week, the 45% of patients showed improvement that increased to 81% at the end of the study. Single confocal criteria was evaluated and results underwent to statistical analysis considering the modification of the microscopical changes during the two treatments. Conclusion: RCM followed the microscopic changes during treatment and enabled to differentiate effects of different actives. Although data are preliminary and based on a limited sample, aceclofenac seems to be effective in the treatment for psoriasis.

Original languageEnglish
Pages (from-to)417-423
Number of pages7
JournalSkin Research and Technology
Volume19
Issue number4
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Non-Steroidal Anti-Inflammatory Agents
Psoriasis
Confocal Microscopy
Steroids
Therapeutics
Histology
aceclofenac

Keywords

  • Plaque psoriasis
  • Reflectance confocal microscopy
  • Therapeutical follow-up
  • Topical treatments

ASJC Scopus subject areas

  • Dermatology

Cite this

Psoriasis plaque test with confocal microscopy : Evaluation of different microscopic response pathways in NSAID and steroid treated lesions. / Ardigò, Marco; Agozzino, Marina; Longo, Caterina; Conti, Andrea; Di Lernia, Vito; Berardesca, Enzo; Pellacani, Giovanni.

In: Skin Research and Technology, Vol. 19, No. 4, 11.2013, p. 417-423.

Research output: Contribution to journalArticle

@article{ca378af0111240efb1375eee7aa7bd46,
title = "Psoriasis plaque test with confocal microscopy: Evaluation of different microscopic response pathways in NSAID and steroid treated lesions",
abstract = "Background: Pathophysiology of psoriasis is complex and characterized by microscopic, specific changes. In vivo reflectance confocal microscopy (RCM) provides tissue and cell morphology information in non-invasive way, generating quasi-histologic resolution. Concerning plaque psoriasis, confocal criteria have been described disclosing high agreement between RCM and conventional histology. Objective: We sought to evaluate the in vivo microscopic changes in plaque psoriasis occurring during treatment with two distinct actives (aceclofenac and betamethason). Methods: A total of 32 patients with psoriasis were recruited. Two lesions from the same body area or symmetrical were evaluated at baseline and after 3-6 weeks by RCM. Results: Aceclofenac induced clinical improvement in 32{\%} of patients after 3 weeks and in 76{\%} after 6 weeks. With betamethason, at the end of the 3rd week, the 45{\%} of patients showed improvement that increased to 81{\%} at the end of the study. Single confocal criteria was evaluated and results underwent to statistical analysis considering the modification of the microscopical changes during the two treatments. Conclusion: RCM followed the microscopic changes during treatment and enabled to differentiate effects of different actives. Although data are preliminary and based on a limited sample, aceclofenac seems to be effective in the treatment for psoriasis.",
keywords = "Plaque psoriasis, Reflectance confocal microscopy, Therapeutical follow-up, Topical treatments",
author = "Marco Ardig{\`o} and Marina Agozzino and Caterina Longo and Andrea Conti and {Di Lernia}, Vito and Enzo Berardesca and Giovanni Pellacani",
year = "2013",
month = "11",
doi = "10.1111/srt.12062",
language = "English",
volume = "19",
pages = "417--423",
journal = "Skin Research and Technology",
issn = "0909-752X",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Psoriasis plaque test with confocal microscopy

T2 - Evaluation of different microscopic response pathways in NSAID and steroid treated lesions

AU - Ardigò, Marco

AU - Agozzino, Marina

AU - Longo, Caterina

AU - Conti, Andrea

AU - Di Lernia, Vito

AU - Berardesca, Enzo

AU - Pellacani, Giovanni

PY - 2013/11

Y1 - 2013/11

N2 - Background: Pathophysiology of psoriasis is complex and characterized by microscopic, specific changes. In vivo reflectance confocal microscopy (RCM) provides tissue and cell morphology information in non-invasive way, generating quasi-histologic resolution. Concerning plaque psoriasis, confocal criteria have been described disclosing high agreement between RCM and conventional histology. Objective: We sought to evaluate the in vivo microscopic changes in plaque psoriasis occurring during treatment with two distinct actives (aceclofenac and betamethason). Methods: A total of 32 patients with psoriasis were recruited. Two lesions from the same body area or symmetrical were evaluated at baseline and after 3-6 weeks by RCM. Results: Aceclofenac induced clinical improvement in 32% of patients after 3 weeks and in 76% after 6 weeks. With betamethason, at the end of the 3rd week, the 45% of patients showed improvement that increased to 81% at the end of the study. Single confocal criteria was evaluated and results underwent to statistical analysis considering the modification of the microscopical changes during the two treatments. Conclusion: RCM followed the microscopic changes during treatment and enabled to differentiate effects of different actives. Although data are preliminary and based on a limited sample, aceclofenac seems to be effective in the treatment for psoriasis.

AB - Background: Pathophysiology of psoriasis is complex and characterized by microscopic, specific changes. In vivo reflectance confocal microscopy (RCM) provides tissue and cell morphology information in non-invasive way, generating quasi-histologic resolution. Concerning plaque psoriasis, confocal criteria have been described disclosing high agreement between RCM and conventional histology. Objective: We sought to evaluate the in vivo microscopic changes in plaque psoriasis occurring during treatment with two distinct actives (aceclofenac and betamethason). Methods: A total of 32 patients with psoriasis were recruited. Two lesions from the same body area or symmetrical were evaluated at baseline and after 3-6 weeks by RCM. Results: Aceclofenac induced clinical improvement in 32% of patients after 3 weeks and in 76% after 6 weeks. With betamethason, at the end of the 3rd week, the 45% of patients showed improvement that increased to 81% at the end of the study. Single confocal criteria was evaluated and results underwent to statistical analysis considering the modification of the microscopical changes during the two treatments. Conclusion: RCM followed the microscopic changes during treatment and enabled to differentiate effects of different actives. Although data are preliminary and based on a limited sample, aceclofenac seems to be effective in the treatment for psoriasis.

KW - Plaque psoriasis

KW - Reflectance confocal microscopy

KW - Therapeutical follow-up

KW - Topical treatments

UR - http://www.scopus.com/inward/record.url?scp=84885471154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885471154&partnerID=8YFLogxK

U2 - 10.1111/srt.12062

DO - 10.1111/srt.12062

M3 - Article

C2 - 23521429

AN - SCOPUS:84885471154

VL - 19

SP - 417

EP - 423

JO - Skin Research and Technology

JF - Skin Research and Technology

SN - 0909-752X

IS - 4

ER -