Psoriatic arthritis: Clinical improvement and correlation with hormone axes in etanercept-treated patients: Annals of the New York Academy of Sciences

Fabiola Atzeni, Rainer H. Straub, Maurizio Cutolo, Piercarlo Sarzi-Puttini

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In a chronic inflammatory disease, such as rheumatoid arthritis (RA), the hypothalamic-pituitary-adrenal axis is altered in three ways: (1) the inflammation-related spontaneous and stimulated secretion of cortisol is inadequate; (2) the inflammation-related secretion of adrenocorticotropic hormone (ACTH) is low; and (3) the levels of adrenal androgens decrease. In patients with RA, long-term therapy with anti-TNF therapy sensitizes the pituitary gland and improves adrenal androgen secretion. We have recently found that the mean serum levels of ACTH, cortisol, 17-hydroxyprogesterone (17OHP), and androstenedione (ASD) in 11 prednisolone-naïve patients with psoriatic arthritis did not markedly change during 12 weeks of etanercept treatment, nor did the serum cortisolACTH ratio. However, the greater increase in serum cortisol in comparison with serum 17OHP or ASD was related to clinical improvement, which indicates that the improvement was more related to the higher cortisol levels.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages176-178
Number of pages3
Volume1193
DOIs
Publication statusPublished - Apr 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1193
ISSN (Print)00778923
ISSN (Electronic)17496632

    Fingerprint

Keywords

  • Cortisol
  • Psoriatic arthritis
  • TNF inhibitors
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Atzeni, F., Straub, R. H., Cutolo, M., & Sarzi-Puttini, P. (2010). Psoriatic arthritis: Clinical improvement and correlation with hormone axes in etanercept-treated patients: Annals of the New York Academy of Sciences. In Annals of the New York Academy of Sciences (Vol. 1193, pp. 176-178). (Annals of the New York Academy of Sciences; Vol. 1193). https://doi.org/10.1111/j.1749-6632.2009.05363.x