PSORS2 markers are not associated with psoriatic arthritis in the Italian population

Emiliano Giardina, Irene Predazzi, Cecilia Sinibaldi, Cristina Peconi, Paolo Amerio, Antonio Costanzo, Andrea Paradisi, Rodolfo Capizzi, Mauro Paradisi, Sergio Chimenti, Egisto Taccari, Giuseppe Novelli

Research output: Contribution to journalArticlepeer-review

Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy characterized by the association of arthritis and psoriasis (Ps). The precise etiology of PsA is unknown, but epidemiological studies supported the existence of a genetic component for the disease. Here we report an association study on a large PsA Italian cohort for DNA variants recently reported as associated alleles at PSORS2 (17q25) in Ps cohorts from the US. We focused on discovering a possible involvement of PSORS2 associated SNPs in pathogenesis of PsA. We selected two SNPs (rs7420, rs734232) within the proximal peak and two SNPs (rs869190 and rs1561946) within distal peak of PSORS2. Our results ruled out PSORS2 alleles as susceptibility factors in arthritis psoriatic patients of Italian origin and suggested that previous linkage signal reported for chromosome 17q25 should be independent on the presence of PsA.

Original languageEnglish
Pages (from-to)120-122
Number of pages3
JournalHuman Heredity
Volume61
Issue number2
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Association study
  • Psoriasis
  • Psoriatic arthritis
  • PSORS2
  • RUNX1

ASJC Scopus subject areas

  • Genetics(clinical)

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