Psychedelics and the essential importance of context

Robin L. Carhart-Harris, Leor Roseman, Eline Haijen, David Erritzoe, Rosalind Watts, Igor Branchi, Mendel Kaelen

Research output: Contribution to journalArticle

Abstract

Psychedelic drugs are making waves as modern trials support their therapeutic potential and various media continue to pique public interest. In this opinion piece, we draw attention to a long-recognised component of the psychedelic treatment model, namely ‘set’ and ‘setting’ – subsumed here under the umbrella term ‘context’. We highlight: (a) the pharmacological mechanisms of classic psychedelics (5-HT2A receptor agonism and associated plasticity) that we believe render their effects exceptionally sensitive to context, (b) a study design for testing assumptions regarding positive interactions between psychedelics and context, and (c) new findings from our group regarding contextual determinants of the quality of a psychedelic experience and how acute experience predicts subsequent long-term mental health outcomes. We hope that this article can: (a) inform on good practice in psychedelic research, (b) provide a roadmap for optimising treatment models, and (c) help tackle unhelpful stigma still surrounding these compounds, while developing an evidence base for long-held assumptions about the critical importance of context in relation to psychedelic use that can help minimise harms and maximise potential benefits.

Original languageEnglish
Pages (from-to)725-731
Number of pages7
JournalJournal of Psychopharmacology
Volume32
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

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Hallucinogens
Receptor, Serotonin, 5-HT2A
Mental Health
Pharmacology
Research
Pharmaceutical Preparations

Keywords

  • Psychedelics
  • psychotherapy
  • serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Carhart-Harris, R. L., Roseman, L., Haijen, E., Erritzoe, D., Watts, R., Branchi, I., & Kaelen, M. (2018). Psychedelics and the essential importance of context. Journal of Psychopharmacology, 32(7), 725-731. https://doi.org/10.1177/0269881118754710

Psychedelics and the essential importance of context. / Carhart-Harris, Robin L.; Roseman, Leor; Haijen, Eline; Erritzoe, David; Watts, Rosalind; Branchi, Igor; Kaelen, Mendel.

In: Journal of Psychopharmacology, Vol. 32, No. 7, 01.07.2018, p. 725-731.

Research output: Contribution to journalArticle

Carhart-Harris, RL, Roseman, L, Haijen, E, Erritzoe, D, Watts, R, Branchi, I & Kaelen, M 2018, 'Psychedelics and the essential importance of context', Journal of Psychopharmacology, vol. 32, no. 7, pp. 725-731. https://doi.org/10.1177/0269881118754710
Carhart-Harris RL, Roseman L, Haijen E, Erritzoe D, Watts R, Branchi I et al. Psychedelics and the essential importance of context. Journal of Psychopharmacology. 2018 Jul 1;32(7):725-731. https://doi.org/10.1177/0269881118754710
Carhart-Harris, Robin L. ; Roseman, Leor ; Haijen, Eline ; Erritzoe, David ; Watts, Rosalind ; Branchi, Igor ; Kaelen, Mendel. / Psychedelics and the essential importance of context. In: Journal of Psychopharmacology. 2018 ; Vol. 32, No. 7. pp. 725-731.
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