TY - JOUR
T1 - Psychiatric, behavioral, and cognitive disorders in patients with extracranial cancers
AU - Pravettoni, Gabriella
AU - Dell’Osso, Bernardo
AU - Bocci, Tommaso
AU - Cortese, Francesca
AU - Ferrucci, Roberta
AU - Lampis, Valentina
AU - Rosci, Chiara
AU - Priori, Alberto
PY - 2018
Y1 - 2018
N2 - Patients with cancer may report neuropsychiatric abnormalities including cognitive impairment, behavioral disturbances, and psychiatric disorders that potentially worsen their quality of life, reduce their treatment response, and aggravate their overall prognosis. Neuropsychiatric disturbances have a different pathophysiology, including immuno-inflammatory and neuroendocrine mechanisms, as a consequence of oncologic treatments (chemo- and radio-therapy). Among clinicians involved in the management of such patients, psychiatrists need to pay particular attention in recognizing behavioral disturbances that arise in oncologic patients, and determining those that may be effectively treated with psychotropic medications, psychotherapeutic interventions, and an integration of them. Through the contribution of different clinicians actively involved in the management of oncological patients, the present review is ultimately aimed at updating psychiatrists in relation to the pathophysiological mechanisms responsible for the onset of cognitive, affective, and behavioral syndromes in these patients, along with epidemiologic and clinical considerations and therapeutic perspectives.
AB - Patients with cancer may report neuropsychiatric abnormalities including cognitive impairment, behavioral disturbances, and psychiatric disorders that potentially worsen their quality of life, reduce their treatment response, and aggravate their overall prognosis. Neuropsychiatric disturbances have a different pathophysiology, including immuno-inflammatory and neuroendocrine mechanisms, as a consequence of oncologic treatments (chemo- and radio-therapy). Among clinicians involved in the management of such patients, psychiatrists need to pay particular attention in recognizing behavioral disturbances that arise in oncologic patients, and determining those that may be effectively treated with psychotropic medications, psychotherapeutic interventions, and an integration of them. Through the contribution of different clinicians actively involved in the management of oncological patients, the present review is ultimately aimed at updating psychiatrists in relation to the pathophysiological mechanisms responsible for the onset of cognitive, affective, and behavioral syndromes in these patients, along with epidemiologic and clinical considerations and therapeutic perspectives.
KW - Cognitive impairment
KW - extracranial cancer
KW - neuropathology
KW - psychiatric symptoms
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=85051084604&partnerID=8YFLogxK
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U2 - 10.1017/S1092852918000883
DO - 10.1017/S1092852918000883
M3 - Article
AN - SCOPUS:85051084604
VL - 23
SP - 388
EP - 401
JO - CNS Spectrums
JF - CNS Spectrums
SN - 1092-8529
IS - 6
ER -