Psychiatric comorbidities in patients from seven families with autosomal dominant cortical tremor, myoclonus, and epilepsy

Antonietta Coppola, Carmela Caccavale, Lia Santulli, Simona Balestrini, Claudia Cagnetti, Laura Licchetta, Marcello Esposito, Francesca Bisulli, Paolo Tinuper, Leandro Provinciali, Carlo Minetti, Federico Zara, Pasquale Striano, Salvatore Striano

Research output: Contribution to journalArticlepeer-review


Objective: The objective of this report was to assess the psychiatric comorbidity in a group of patients affected by autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME). Methods: Reliable and validated psychodiagnostic scales including the BDI (Beck Depression Inventory), STAI-Y1 and 2 (State-Trait Anxiety Inventory - Y; 1 and 2), MMPI-2 (Minnesota Multiphasic Personality Inventory - 2), and QoLIE-31 (Quality of Life in Epilepsy Inventory - 31) were administered to 20 patients with ADCME, 20 patients with juvenile myoclonic epilepsy (JME), and 20 healthy controls. Results: There was a higher prevalence of mood disorders in patients with ADCME compared to patients with JME and healthy controls, particularly depression (p = 0.035 and p = 0.017, respectively) and state anxiety (p = 0.024 and p = 0.019, respectively). Trait anxiety was not different from JME (p = 0.102) but higher than healthy controls (p = 0.017). The myoclonus score positively correlated with both state (rho: 0.58, p = 0.042) and trait anxiety (rho: 0.65, p = 0.011). These psychiatric features were also often associated with pathological traits of personality: paranoid (OR: 25.7, p = 0.003), psychasthenia (OR: 7.0, p = 0.023), schizophrenia (OR: 8.5, p = 0.011), and hypomania (OR: 5.5, p = 0.022). Finally, in patients with ADCME, decreased quality of life correlated with these psychiatric symptoms. Significance: Patients with ADCME show a significant psychiatric burden that impairs their quality of life. A comprehensive psychiatric evaluation should be offered at the time of diagnosis to detect these comorbidities and to treat them.

Original languageEnglish
Pages (from-to)38-43
Number of pages6
JournalEpilepsy and Behavior
Publication statusPublished - Mar 1 2016


  • Anxiety
  • Depression
  • Epilepsy
  • Myoclonus
  • Personality disorders
  • Quality of life

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology


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