TY - JOUR
T1 - Psychiatric Disorders in Alzheimer Disease With the Presenilin-1 L226F Mutation
AU - Bartesaghi, Francesca
AU - Rosci, Chiara Emilia
AU - Rassiga, Cecilia
AU - Barbieri, Valentina
AU - Gambini, Orsola
AU - Floro, Stefano
AU - D'Arrigo, Andrea Maria
AU - Del Sole, Angelo
AU - Scarpini, Elio Angelo
AU - Galimberti, Daniela
AU - Priori, Alberto
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The presenilin-1 (PSEN1) L226F mutation has been linked to very early onset of prominent behavioral and psychiatric disturbances followed by cognitive decline within a few years. We report a novel case of early-onset Alzheimer disease that was originally diagnosed as psychotic depression in a patient with this gene mutation. We also compare our patient's clinical data to those of other cases of this mutation that have been described in the literature. Because atypical behavioral and psychiatric disturbances in young (<40 years) individuals can herald Alzheimer disease, a tight collaboration between psychiatrists and neurologists is crucial for an early diagnosis.
AB - The presenilin-1 (PSEN1) L226F mutation has been linked to very early onset of prominent behavioral and psychiatric disturbances followed by cognitive decline within a few years. We report a novel case of early-onset Alzheimer disease that was originally diagnosed as psychotic depression in a patient with this gene mutation. We also compare our patient's clinical data to those of other cases of this mutation that have been described in the literature. Because atypical behavioral and psychiatric disturbances in young (<40 years) individuals can herald Alzheimer disease, a tight collaboration between psychiatrists and neurologists is crucial for an early diagnosis.
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U2 - 10.1097/WNN.0000000000000249
DO - 10.1097/WNN.0000000000000249
M3 - Article
C2 - 33264156
AN - SCOPUS:85097122460
VL - 33
SP - 278
EP - 282
JO - Cognitive and Behavioral Neurology
JF - Cognitive and Behavioral Neurology
SN - 1543-3633
IS - 4
ER -