Psychiatric Disorders in Alzheimer Disease With the Presenilin-1 L226F Mutation

Francesca Bartesaghi, Chiara Emilia Rosci, Cecilia Rassiga, Valentina Barbieri, Orsola Gambini, Stefano Floro, Andrea Maria D'Arrigo, Angelo Del Sole, Elio Angelo Scarpini, Daniela Galimberti, Alberto Priori

Research output: Contribution to journalArticlepeer-review


The presenilin-1 (PSEN1) L226F mutation has been linked to very early onset of prominent behavioral and psychiatric disturbances followed by cognitive decline within a few years. We report a novel case of early-onset Alzheimer disease that was originally diagnosed as psychotic depression in a patient with this gene mutation. We also compare our patient's clinical data to those of other cases of this mutation that have been described in the literature. Because atypical behavioral and psychiatric disturbances in young (<40 years) individuals can herald Alzheimer disease, a tight collaboration between psychiatrists and neurologists is crucial for an early diagnosis.

Original languageEnglish
Pages (from-to)278-282
Number of pages5
JournalCognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
Issue number4
Publication statusPublished - Dec 1 2020

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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