Psychiatric disorders in patients with essential tremor

Giovanni Fabbrini, Isabella Berardelli, Marika Falla, Germana Moretti, Massimo Pasquini, Marta Altieri, Giovanni Defazio, Massimo Biondi, Alfredo Berardelli

Research output: Contribution to journalArticlepeer-review


Background: Previous studies have reported that a consistent proportion of patients with Essential Tremor may have psychiatric disorders but it is unclear whether these disorders are increased in frequency as compared to healthy subjects. Methods: In a case-control study, we adopted the structured interviews for DSM-IV, SCID-I and SCID-II, to investigate psychiatric and personality disorders in 37 ET patients and 34 healthy subjects. As cognitive changes in ET may be a confounding factor we enrolled patients and healthy control subjects without cognitive dysfunction. Results: SCID-I showed that Axis-I psychiatric disorders, mainly depressive disorders, were more frequent in ET patients (20 of 37; 54%) than in healthy subjects (8 of 34; 22%) (p <0.01). Depressive disorders were more frequent in patients with a family history of ET (p <0.05) in comparison to patients without a family history. SCID-II disclosed that the frequency of personality disorders was similar in patients with ET and healthy subjects. Conclusion: Psychiatric disorders may be associated to the neurological manifestations of ET.

Original languageEnglish
Pages (from-to)971-973
Number of pages3
JournalParkinsonism and Related Disorders
Issue number8
Publication statusPublished - Sep 2012


  • Anxiety
  • Depression
  • Essential tremor
  • Personality disorders

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology


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