Psychiatric disturbances in patients with progressive supranuclear palsy: A case-control study

Maria Carmela Bloise, Isabella Berardelli, Valentina Roselli, Massimo Pasquini, Paola Stirpe, Carlo Colosimo, Alfredo Berardelli, Giovanni Fabbrini

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: To investigate the frequency and the different types of psychiatric disturbances in PSP patients using validated psychiatric instruments. Methods: We conducted a case-control study using the Structured Clinical Interview (SCID-I) for DSM-IV to investigate psychiatric disorders in 28 PSP patients and 28 age and gender matched healthy controls. PSP severity was scored using the PSP rating scale cognitive functions were assessed using the Montreal Cognitive Assessment scale and the Frontal Assessment Battery scale. Results: SCID-I disclosed that psychiatric disturbances were more frequent in PSP patients (53%) than in healthy controls (17.8%) (p=0.005). Psychiatric disorders in PSP patients were characterized by mood disorders. Depression due to PSP was the most frequent diagnosis and was found in 8 of the 15 patients with depressive disorders. None of the PSP patients had a diagnosis of other SCID-I disorders. No clinical or demographic differences were found when comparing PSP patients with and without psychiatric disturbances. Conclusions: Psychiatric disturbances, namely depressive disorders, were more frequent in PSP patients than in controls. A thorough evaluation of psychiatric disorders is important to insure appropriate treatment of PSP patients.

Original languageEnglish
Pages (from-to)965-968
Number of pages4
JournalParkinsonism and Related Disorders
Volume20
Issue number9
DOIs
Publication statusPublished - 2014

Fingerprint

Progressive Supranuclear Palsy
Psychiatry
Case-Control Studies
Depressive Disorder
Primary Spontaneous Pneumothorax
Mood Disorders
Diagnostic and Statistical Manual of Mental Disorders
Cognition

Keywords

  • Anxiety
  • Depression
  • Progressive supranuclear palsy
  • SCID-I

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Psychiatric disturbances in patients with progressive supranuclear palsy : A case-control study. / Bloise, Maria Carmela; Berardelli, Isabella; Roselli, Valentina; Pasquini, Massimo; Stirpe, Paola; Colosimo, Carlo; Berardelli, Alfredo; Fabbrini, Giovanni.

In: Parkinsonism and Related Disorders, Vol. 20, No. 9, 2014, p. 965-968.

Research output: Contribution to journalArticle

Bloise, Maria Carmela ; Berardelli, Isabella ; Roselli, Valentina ; Pasquini, Massimo ; Stirpe, Paola ; Colosimo, Carlo ; Berardelli, Alfredo ; Fabbrini, Giovanni. / Psychiatric disturbances in patients with progressive supranuclear palsy : A case-control study. In: Parkinsonism and Related Disorders. 2014 ; Vol. 20, No. 9. pp. 965-968.
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