Psychiatric problems in fibromyalgia

Clinical and neurobiological links between mood disorders and fibromyalgia

A. Alciati, P. Sgiarovello, F. Atzeni, P. Sarzi-Puttini

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective. To review the literature addressing the relationship between mood disorders and fibromyalgia/chron-ic pain and our current understanding of overlapping pathophysiological processes and pain and depression circuitry. Methods. We selectively reviewed articles on the co-occurrence of mood disorders and fibromyalgia/chronic pain published between 1990 and July 2012 in PubMed. Bibliographies and cross references were considered and included when appropriate. Results. Forty-nine out of 138 publications were retained for review. The vast majority of the studies found an association between depression and fibromyalgia. There is evidence that depression is often accompanied by symptoms of opposite polarity characterised by heights of mood, thinking and behaviour that have a considerable impact on pharmacological treatment. Recent developments support the view that the high rates of fibromyalgia and mood disorder comorbidity is generated by largely overlapping pathophysiological processes in the brain, that provide a neurobiological basis for the bidirectional, mutually exacerbating and disabling relationship between pain and depression. Conclusions. The finding of comparable pathophysiological characteristics of pain and depression provides a framework for understanding the relationship between the two conditions and sheds some light on neurobio-logical and therapeutic aspects.

Original languageEnglish
Pages (from-to)268-274
Number of pages7
JournalReumatismo
Volume64
Issue number4
Publication statusPublished - 2012

Fingerprint

Fibromyalgia
Mood Disorders
Psychiatry
Depression
Pain
Bibliography
PubMed
Chronic Pain
Publications
Comorbidity
Pharmacology
Brain
Therapeutics

Keywords

  • Comorbidity
  • Depression
  • Fibromyalgia
  • Pain

ASJC Scopus subject areas

  • Rheumatology

Cite this

Alciati, A., Sgiarovello, P., Atzeni, F., & Sarzi-Puttini, P. (2012). Psychiatric problems in fibromyalgia: Clinical and neurobiological links between mood disorders and fibromyalgia. Reumatismo, 64(4), 268-274.

Psychiatric problems in fibromyalgia : Clinical and neurobiological links between mood disorders and fibromyalgia. / Alciati, A.; Sgiarovello, P.; Atzeni, F.; Sarzi-Puttini, P.

In: Reumatismo, Vol. 64, No. 4, 2012, p. 268-274.

Research output: Contribution to journalArticle

Alciati, A, Sgiarovello, P, Atzeni, F & Sarzi-Puttini, P 2012, 'Psychiatric problems in fibromyalgia: Clinical and neurobiological links between mood disorders and fibromyalgia', Reumatismo, vol. 64, no. 4, pp. 268-274.
Alciati, A. ; Sgiarovello, P. ; Atzeni, F. ; Sarzi-Puttini, P. / Psychiatric problems in fibromyalgia : Clinical and neurobiological links between mood disorders and fibromyalgia. In: Reumatismo. 2012 ; Vol. 64, No. 4. pp. 268-274.
@article{3640e7ca7fd240a3b5243d182283f8f7,
title = "Psychiatric problems in fibromyalgia: Clinical and neurobiological links between mood disorders and fibromyalgia",
abstract = "Objective. To review the literature addressing the relationship between mood disorders and fibromyalgia/chron-ic pain and our current understanding of overlapping pathophysiological processes and pain and depression circuitry. Methods. We selectively reviewed articles on the co-occurrence of mood disorders and fibromyalgia/chronic pain published between 1990 and July 2012 in PubMed. Bibliographies and cross references were considered and included when appropriate. Results. Forty-nine out of 138 publications were retained for review. The vast majority of the studies found an association between depression and fibromyalgia. There is evidence that depression is often accompanied by symptoms of opposite polarity characterised by heights of mood, thinking and behaviour that have a considerable impact on pharmacological treatment. Recent developments support the view that the high rates of fibromyalgia and mood disorder comorbidity is generated by largely overlapping pathophysiological processes in the brain, that provide a neurobiological basis for the bidirectional, mutually exacerbating and disabling relationship between pain and depression. Conclusions. The finding of comparable pathophysiological characteristics of pain and depression provides a framework for understanding the relationship between the two conditions and sheds some light on neurobio-logical and therapeutic aspects.",
keywords = "Comorbidity, Depression, Fibromyalgia, Pain",
author = "A. Alciati and P. Sgiarovello and F. Atzeni and P. Sarzi-Puttini",
year = "2012",
language = "English",
volume = "64",
pages = "268--274",
journal = "Reumatismo",
issn = "0048-7449",
publisher = "PAGEPRESS PUBL",
number = "4",

}

TY - JOUR

T1 - Psychiatric problems in fibromyalgia

T2 - Clinical and neurobiological links between mood disorders and fibromyalgia

AU - Alciati, A.

AU - Sgiarovello, P.

AU - Atzeni, F.

AU - Sarzi-Puttini, P.

PY - 2012

Y1 - 2012

N2 - Objective. To review the literature addressing the relationship between mood disorders and fibromyalgia/chron-ic pain and our current understanding of overlapping pathophysiological processes and pain and depression circuitry. Methods. We selectively reviewed articles on the co-occurrence of mood disorders and fibromyalgia/chronic pain published between 1990 and July 2012 in PubMed. Bibliographies and cross references were considered and included when appropriate. Results. Forty-nine out of 138 publications were retained for review. The vast majority of the studies found an association between depression and fibromyalgia. There is evidence that depression is often accompanied by symptoms of opposite polarity characterised by heights of mood, thinking and behaviour that have a considerable impact on pharmacological treatment. Recent developments support the view that the high rates of fibromyalgia and mood disorder comorbidity is generated by largely overlapping pathophysiological processes in the brain, that provide a neurobiological basis for the bidirectional, mutually exacerbating and disabling relationship between pain and depression. Conclusions. The finding of comparable pathophysiological characteristics of pain and depression provides a framework for understanding the relationship between the two conditions and sheds some light on neurobio-logical and therapeutic aspects.

AB - Objective. To review the literature addressing the relationship between mood disorders and fibromyalgia/chron-ic pain and our current understanding of overlapping pathophysiological processes and pain and depression circuitry. Methods. We selectively reviewed articles on the co-occurrence of mood disorders and fibromyalgia/chronic pain published between 1990 and July 2012 in PubMed. Bibliographies and cross references were considered and included when appropriate. Results. Forty-nine out of 138 publications were retained for review. The vast majority of the studies found an association between depression and fibromyalgia. There is evidence that depression is often accompanied by symptoms of opposite polarity characterised by heights of mood, thinking and behaviour that have a considerable impact on pharmacological treatment. Recent developments support the view that the high rates of fibromyalgia and mood disorder comorbidity is generated by largely overlapping pathophysiological processes in the brain, that provide a neurobiological basis for the bidirectional, mutually exacerbating and disabling relationship between pain and depression. Conclusions. The finding of comparable pathophysiological characteristics of pain and depression provides a framework for understanding the relationship between the two conditions and sheds some light on neurobio-logical and therapeutic aspects.

KW - Comorbidity

KW - Depression

KW - Fibromyalgia

KW - Pain

UR - http://www.scopus.com/inward/record.url?scp=84867148689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867148689&partnerID=8YFLogxK

M3 - Article

VL - 64

SP - 268

EP - 274

JO - Reumatismo

JF - Reumatismo

SN - 0048-7449

IS - 4

ER -