Psychiatric profile of motor subtypes of de novo drug-naïve Parkinson's disease patients

Francesca Assogna, Clelia Pellicano, Luca Cravello, Cinzia Savini, Mariangela Pierantozzi, Bruno Mercuri, Carlo Caltagirone, Francesco E. Pontieri, Gianfranco Spalletta, Alessandro Stefani

Research output: Contribution to journalArticlepeer-review


Background: Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder. It is well established that different motor subtypes of PD evolve with different clinical courses and prognoses. The complete psychiatric profile underlying these different phenotypes since the very early stage of the disease is debated. Aims of the study: We aimed at investigating the psychiatric profile of the three motor subtypes of PD (akinetic-rigid, tremor-dominant, and mixed) in de novo drug-naïve patients with PD. Methods: Sixty-eight patients with PD, divided into 39 akinetic-rigid (AR), seven mixed (MIX), and 22 tremor-dominant (TD) patients underwent a complete assessment of psychiatric, cognitive, and motor symptoms. Results: No significant differences were found among groups. Conclusions: Our results suggest that a differentiation of the psychiatric symptoms associated with specific motor subtypes of PD is not detectable in de novo drug-naïve patients. Previous evidence that emerges later along the disease progression may be a consequence of the dopaminergic and nondopaminergic damage increase.

Original languageEnglish
JournalBrain and Behavior
Publication statusAccepted/In press - Jan 1 2018


  • movement disorders
  • neurodegenerative disorders
  • neuropsychology
  • Parkinson's disease
  • psychiatry

ASJC Scopus subject areas

  • Behavioral Neuroscience


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