Psychiatry meets pharmacogenetics for the treatment of revolving door patients with psychiatric disorders

Francesco Panza, Madia Lozupone, Eleonora Stella, Lucia Lofano, Carolina Gravina, Maria Urbano, Antonio Daniele, Antonello Bellomo, Giancarlo Logroscino, Antonio Greco, Davide Seripa

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Abstract

INTRODUCTION: Therapeutic failures (TFs) and adverse drug reactions (ADRs), together with the recurring nature of the clinical course of psychiatric disorders, mainly bipolar disorders (BDs), strongly contributed to the prevalence and frequency of hospital readmissions observed in these patients. This is the revolving door (RD) condition, dramatically rising costs for the management of these patients in psychiatric settings. Areas covered: We searched in the medical literature until May 2016 to review the role of functional variants in the cytochrome P450 (CYP) 2D6 gene on observed ADRs and TFs in RD patients with BDs, conferring a different capacity to metabolize psychotropic drugs. Expert commentary: CYP2D6 functional polymorphisms might directly contributed to the prevalence and frequency of the RD condition, commonly observed in BD patients. Although several environmental and socio-demographic/diagnostic variables such as alcohol/drug abuse, and medication non-compliance accounted for a significant proportion of the ability to predict RD prevalence and frequency, the pharmacogenetics of CYP, particularly CYP2D6, may help to identify BD patients at risk for ADRs and TFs. These patients may be addressed towards alternative treatments, thus improving their quality of life, and reducing RD prevalence and frequency and the overall costs for their management.

Original languageEnglish
Pages (from-to)1357-1369
Number of pages13
JournalExpert Review of Neurotherapeutics
Volume16
Issue number12
DOIs
Publication statusPublished - Dec 2016

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Keywords

  • Journal Article

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