Abstract
Objective: To investigate the effects of soy isoflavones on mood and cognitive function in postmenopausal women. Design: Randomized, double-blind, cross-over, placebo-controlled trial. Setting: University Hospital, Milan, Italy; A.G.UN.CO. Obstetrics and Gynaecology Centre, Rome, Italy. Patient(s): Seventy-eight postmenopausal women. Intervention(s): We administered 60 mg/day isoflavones or placebo for 6 months. After a washout period of 1 month, the patients who had been treated with phytoestrogens received placebo, and those who previously received placebo were administered phytoestrogens (for 6 months). Main Outcome Measure(s): Cognitive performance and mood were assessed by a battery of tests at the end of each treatment period. At the end of the study, the patients were also asked whether they preferred the first or second treatment. Result(s): The 17 scores on cognitive performance test and the 6 for mood assessments 6 showed an advantage for the treatment with phytoestrogens. Similarly, of the 8 visual analogue scales used to indicate mood, 7 improved significantly after the treatment with phytoestrogens. Moreover, 49 patients preferred phytoestrogens, 9 placebo, and 18 had no preference. The preference was not related to the order of treatment. Conclusion(s): These results suggest that isoflavones may have positive effects on postmenopausal women improving cognitive performance and mood.
| Original language | English |
|---|---|
| Pages (from-to) | 972-978 |
| Number of pages | 7 |
| Journal | Fertility and Sterility |
| Volume | 85 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2006 |
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Keywords
- Cognitive performance
- Estrogens
- Mood
- Phytoestrogens
- Postmenopause
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women : A randomized, double-blind, crossover, placebo-controlled study. / Casini, Maria Luisa; Marelli, Guido; Papaleo, Enrico; Ferrari, Augusto; D'Ambrosio, Francesco; Unfer, Vittorio.
In: Fertility and Sterility, Vol. 85, No. 4, 04.2006, p. 972-978.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women
T2 - A randomized, double-blind, crossover, placebo-controlled study
AU - Casini, Maria Luisa
AU - Marelli, Guido
AU - Papaleo, Enrico
AU - Ferrari, Augusto
AU - D'Ambrosio, Francesco
AU - Unfer, Vittorio
PY - 2006/4
Y1 - 2006/4
N2 - Objective: To investigate the effects of soy isoflavones on mood and cognitive function in postmenopausal women. Design: Randomized, double-blind, cross-over, placebo-controlled trial. Setting: University Hospital, Milan, Italy; A.G.UN.CO. Obstetrics and Gynaecology Centre, Rome, Italy. Patient(s): Seventy-eight postmenopausal women. Intervention(s): We administered 60 mg/day isoflavones or placebo for 6 months. After a washout period of 1 month, the patients who had been treated with phytoestrogens received placebo, and those who previously received placebo were administered phytoestrogens (for 6 months). Main Outcome Measure(s): Cognitive performance and mood were assessed by a battery of tests at the end of each treatment period. At the end of the study, the patients were also asked whether they preferred the first or second treatment. Result(s): The 17 scores on cognitive performance test and the 6 for mood assessments 6 showed an advantage for the treatment with phytoestrogens. Similarly, of the 8 visual analogue scales used to indicate mood, 7 improved significantly after the treatment with phytoestrogens. Moreover, 49 patients preferred phytoestrogens, 9 placebo, and 18 had no preference. The preference was not related to the order of treatment. Conclusion(s): These results suggest that isoflavones may have positive effects on postmenopausal women improving cognitive performance and mood.
AB - Objective: To investigate the effects of soy isoflavones on mood and cognitive function in postmenopausal women. Design: Randomized, double-blind, cross-over, placebo-controlled trial. Setting: University Hospital, Milan, Italy; A.G.UN.CO. Obstetrics and Gynaecology Centre, Rome, Italy. Patient(s): Seventy-eight postmenopausal women. Intervention(s): We administered 60 mg/day isoflavones or placebo for 6 months. After a washout period of 1 month, the patients who had been treated with phytoestrogens received placebo, and those who previously received placebo were administered phytoestrogens (for 6 months). Main Outcome Measure(s): Cognitive performance and mood were assessed by a battery of tests at the end of each treatment period. At the end of the study, the patients were also asked whether they preferred the first or second treatment. Result(s): The 17 scores on cognitive performance test and the 6 for mood assessments 6 showed an advantage for the treatment with phytoestrogens. Similarly, of the 8 visual analogue scales used to indicate mood, 7 improved significantly after the treatment with phytoestrogens. Moreover, 49 patients preferred phytoestrogens, 9 placebo, and 18 had no preference. The preference was not related to the order of treatment. Conclusion(s): These results suggest that isoflavones may have positive effects on postmenopausal women improving cognitive performance and mood.
KW - Cognitive performance
KW - Estrogens
KW - Mood
KW - Phytoestrogens
KW - Postmenopause
UR - http://www.scopus.com/inward/record.url?scp=33645390839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645390839&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2005.09.048
DO - 10.1016/j.fertnstert.2005.09.048
M3 - Article
C2 - 16580383
AN - SCOPUS:33645390839
VL - 85
SP - 972
EP - 978
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 4
ER -