TY - JOUR
T1 - Psychological response to cancer
T2 - Role of 5-HTTLPR genetic polymorphism of serotonin transporter
AU - Schillani, Giulia
AU - Martinis, Elisabetta
AU - Capozzo, Maria Anna
AU - Era, Daniel
AU - Cristante, Tania
AU - Mustacchi, Giorgio
AU - Conte, Maria Anna
AU - De Vanna, Maurizio
AU - Grassi, Luigi
AU - Giraldi, Tullio
PY - 2010
Y1 - 2010
N2 - Background: 5-HTTLPR genetic polymorphism of serotonin transporter (SERT) and stressful life events facilitate depression. The aim of this investigation was therefore to determine the correlations between SERT polymorphism and mental adjustement to cancer. Patients and Methods: Breast cancer patients early after surgery, and subjects with various advanced tumours were recruited, evaluated using the Mini Mental Adjustment to Cancer Scale and Hospital Anxiety and Depression Scale (HADS), and genotyped. Results: In early breast cancer patients (n=53), hopelessness-helplessness (HH) and anxious preoccupation (AP) significantly correlated with depression and anxiety; avoidance (AV) correlated with anxiety. Advanced cancer patients (n=73) displayed similar correlations, and a negative correlation of HADS depression with fighting spirit (FS) and AV. The stratification for 5-HTTLPR showed that early breast cancer carriers of the LIL variant displayed a significant correlation between HH and depression. Conclusion: Among early breast cancer patients, a specific set, characterized by their 5-HTTLPR variant, display differential correlations between HH and depression, with possible implications for treatment options.
AB - Background: 5-HTTLPR genetic polymorphism of serotonin transporter (SERT) and stressful life events facilitate depression. The aim of this investigation was therefore to determine the correlations between SERT polymorphism and mental adjustement to cancer. Patients and Methods: Breast cancer patients early after surgery, and subjects with various advanced tumours were recruited, evaluated using the Mini Mental Adjustment to Cancer Scale and Hospital Anxiety and Depression Scale (HADS), and genotyped. Results: In early breast cancer patients (n=53), hopelessness-helplessness (HH) and anxious preoccupation (AP) significantly correlated with depression and anxiety; avoidance (AV) correlated with anxiety. Advanced cancer patients (n=73) displayed similar correlations, and a negative correlation of HADS depression with fighting spirit (FS) and AV. The stratification for 5-HTTLPR showed that early breast cancer carriers of the LIL variant displayed a significant correlation between HH and depression. Conclusion: Among early breast cancer patients, a specific set, characterized by their 5-HTTLPR variant, display differential correlations between HH and depression, with possible implications for treatment options.
KW - 5-HTTLPR polymorphism
KW - Anxiety
KW - Cancer
KW - Depression
KW - Mental adjustment to cancer
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M3 - Article
C2 - 20944177
AN - SCOPUS:77958559570
VL - 30
SP - 3823
EP - 3826
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 9
ER -