Psychopharmacogenetics of opioids

Alberto Oliverio, Claudio Castellano, Stefano Puglisi-Allegra

Research output: Contribution to journalArticlepeer-review


Different strains of mice show different reactivity to opioids. There are strains in which opioids produce a high analgesic effect and catatonia, and strains in which opioid administration results in hyperactive behaviour. Findings obtained by different research groups using a psychopharmacogenetic approach indicate that the monoamines play a basic role in opiate-induced hyperactivity, and that strain differences in the behavioural profile of opioids may be ascribed to differences in the receptor types at the brain level.

Original languageEnglish
Pages (from-to)350-352
Number of pages3
JournalTrends in Pharmacological Sciences
Issue numberC
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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