Abstract
The aim of this study was to comparatively evaluate the long-term effects of psyllium husk and guar gum supplementation on metabolic syndrome (MS) components. We randomised 141 MS patients to soluble psyllium husk powder or guar gum 3.5 g t.i.d. to be taken 20 min before the main 2 meals, or to a standard diet for a cumulative period of 6 months. Both fibres significantly improved body mass index (-7.2% vs. -6.5%), fasting plasma glucose (-27.9% vs. -11.1%) and insulin (-20.4% vs. -10.8%), HOMA Index (-39.2% vs. -16.7%), glycated haemoglobin (-10.4% vs. -10.3%), low-density lipoprotein cholesterol (-7.9% vs. -8.5%) and apolipoprotein B (-10.5% vs. -5.6%), after 6 months of treatment. Only the psyllium supplementation exerted a significant improvement on plasma triglyceride concentration (-13.3%) and systolic (-3.9%) and diastolic blood pressure (-2.6%). No significant difference was observed regarding the standard diet group in comparison to the baseline. On the basis of our data, psyllium could be more strongly indicated for patients that have to reduce a large number of cardiovascular risk factors, while guar gum could be more rapidly efficacious in strengthening the effect of diets aimed at reducing body weight.
| Original language | English |
|---|---|
| Pages (from-to) | 47-54 |
| Number of pages | 8 |
| Journal | Mediterranean Journal of Nutrition and Metabolism |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 2010 |
Fingerprint
Keywords
- Cardiovascular risk
- Hypercholesterolaemia
- Hyperglycaemia
- Hypertension
- Hypertriglyceridaemia
- Metabolic syndrome
- Soluble fibres
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Food Science
- Nutrition and Dietetics
Cite this
Psyllium improves dyslipidaemia, hyperglycaemia and hypertension, while guar gum reduces body weight more rapidly in patients affected by metabolic syndrome following an AHA Step 2 diet. / Cicero, Arrigo F G; Derosa, Giuseppe; Bove, Marilisa; Imola, Fabrizio; Borghi, Claudio; Gaddi, Antonio V.
In: Mediterranean Journal of Nutrition and Metabolism, Vol. 3, No. 1, 04.2010, p. 47-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Psyllium improves dyslipidaemia, hyperglycaemia and hypertension, while guar gum reduces body weight more rapidly in patients affected by metabolic syndrome following an AHA Step 2 diet
AU - Cicero, Arrigo F G
AU - Derosa, Giuseppe
AU - Bove, Marilisa
AU - Imola, Fabrizio
AU - Borghi, Claudio
AU - Gaddi, Antonio V.
PY - 2010/4
Y1 - 2010/4
N2 - The aim of this study was to comparatively evaluate the long-term effects of psyllium husk and guar gum supplementation on metabolic syndrome (MS) components. We randomised 141 MS patients to soluble psyllium husk powder or guar gum 3.5 g t.i.d. to be taken 20 min before the main 2 meals, or to a standard diet for a cumulative period of 6 months. Both fibres significantly improved body mass index (-7.2% vs. -6.5%), fasting plasma glucose (-27.9% vs. -11.1%) and insulin (-20.4% vs. -10.8%), HOMA Index (-39.2% vs. -16.7%), glycated haemoglobin (-10.4% vs. -10.3%), low-density lipoprotein cholesterol (-7.9% vs. -8.5%) and apolipoprotein B (-10.5% vs. -5.6%), after 6 months of treatment. Only the psyllium supplementation exerted a significant improvement on plasma triglyceride concentration (-13.3%) and systolic (-3.9%) and diastolic blood pressure (-2.6%). No significant difference was observed regarding the standard diet group in comparison to the baseline. On the basis of our data, psyllium could be more strongly indicated for patients that have to reduce a large number of cardiovascular risk factors, while guar gum could be more rapidly efficacious in strengthening the effect of diets aimed at reducing body weight.
AB - The aim of this study was to comparatively evaluate the long-term effects of psyllium husk and guar gum supplementation on metabolic syndrome (MS) components. We randomised 141 MS patients to soluble psyllium husk powder or guar gum 3.5 g t.i.d. to be taken 20 min before the main 2 meals, or to a standard diet for a cumulative period of 6 months. Both fibres significantly improved body mass index (-7.2% vs. -6.5%), fasting plasma glucose (-27.9% vs. -11.1%) and insulin (-20.4% vs. -10.8%), HOMA Index (-39.2% vs. -16.7%), glycated haemoglobin (-10.4% vs. -10.3%), low-density lipoprotein cholesterol (-7.9% vs. -8.5%) and apolipoprotein B (-10.5% vs. -5.6%), after 6 months of treatment. Only the psyllium supplementation exerted a significant improvement on plasma triglyceride concentration (-13.3%) and systolic (-3.9%) and diastolic blood pressure (-2.6%). No significant difference was observed regarding the standard diet group in comparison to the baseline. On the basis of our data, psyllium could be more strongly indicated for patients that have to reduce a large number of cardiovascular risk factors, while guar gum could be more rapidly efficacious in strengthening the effect of diets aimed at reducing body weight.
KW - Cardiovascular risk
KW - Hypercholesterolaemia
KW - Hyperglycaemia
KW - Hypertension
KW - Hypertriglyceridaemia
KW - Metabolic syndrome
KW - Soluble fibres
UR - http://www.scopus.com/inward/record.url?scp=77949918413&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949918413&partnerID=8YFLogxK
U2 - 10.1007/s12349-009-0056-1
DO - 10.1007/s12349-009-0056-1
M3 - Article
VL - 3
SP - 47
EP - 54
JO - Mediterranean Journal of Nutrition and Metabolism
JF - Mediterranean Journal of Nutrition and Metabolism
SN - 1973-798X
IS - 1
ER -