Psyllium improves dyslipidaemia, hyperglycaemia and hypertension, while guar gum reduces body weight more rapidly in patients affected by metabolic syndrome following an AHA Step 2 diet

Arrigo F G Cicero, Giuseppe Derosa, Marilisa Bove, Fabrizio Imola, Claudio Borghi, Antonio V. Gaddi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The aim of this study was to comparatively evaluate the long-term effects of psyllium husk and guar gum supplementation on metabolic syndrome (MS) components. We randomised 141 MS patients to soluble psyllium husk powder or guar gum 3.5 g t.i.d. to be taken 20 min before the main 2 meals, or to a standard diet for a cumulative period of 6 months. Both fibres significantly improved body mass index (-7.2% vs. -6.5%), fasting plasma glucose (-27.9% vs. -11.1%) and insulin (-20.4% vs. -10.8%), HOMA Index (-39.2% vs. -16.7%), glycated haemoglobin (-10.4% vs. -10.3%), low-density lipoprotein cholesterol (-7.9% vs. -8.5%) and apolipoprotein B (-10.5% vs. -5.6%), after 6 months of treatment. Only the psyllium supplementation exerted a significant improvement on plasma triglyceride concentration (-13.3%) and systolic (-3.9%) and diastolic blood pressure (-2.6%). No significant difference was observed regarding the standard diet group in comparison to the baseline. On the basis of our data, psyllium could be more strongly indicated for patients that have to reduce a large number of cardiovascular risk factors, while guar gum could be more rapidly efficacious in strengthening the effect of diets aimed at reducing body weight.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalMediterranean Journal of Nutrition and Metabolism
Volume3
Issue number1
DOIs
Publication statusPublished - Apr 2010

Fingerprint

guar gum
Psyllium
metabolic syndrome
hyperlipidemia
hyperglycemia
Dyslipidemias
Hyperglycemia
hypertension
Body Weight
Diet
Hypertension
hulls
body weight
diet
apolipoprotein B
glycohemoglobin
diastolic blood pressure
systolic blood pressure
Blood Pressure
meals (menu)

Keywords

  • Cardiovascular risk
  • Hypercholesterolaemia
  • Hyperglycaemia
  • Hypertension
  • Hypertriglyceridaemia
  • Metabolic syndrome
  • Soluble fibres

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Food Science
  • Nutrition and Dietetics

Cite this

Psyllium improves dyslipidaemia, hyperglycaemia and hypertension, while guar gum reduces body weight more rapidly in patients affected by metabolic syndrome following an AHA Step 2 diet. / Cicero, Arrigo F G; Derosa, Giuseppe; Bove, Marilisa; Imola, Fabrizio; Borghi, Claudio; Gaddi, Antonio V.

In: Mediterranean Journal of Nutrition and Metabolism, Vol. 3, No. 1, 04.2010, p. 47-54.

Research output: Contribution to journalArticle

@article{78090c2ead5b4f4ebd2ff6d8fff09407,
title = "Psyllium improves dyslipidaemia, hyperglycaemia and hypertension, while guar gum reduces body weight more rapidly in patients affected by metabolic syndrome following an AHA Step 2 diet",
abstract = "The aim of this study was to comparatively evaluate the long-term effects of psyllium husk and guar gum supplementation on metabolic syndrome (MS) components. We randomised 141 MS patients to soluble psyllium husk powder or guar gum 3.5 g t.i.d. to be taken 20 min before the main 2 meals, or to a standard diet for a cumulative period of 6 months. Both fibres significantly improved body mass index (-7.2{\%} vs. -6.5{\%}), fasting plasma glucose (-27.9{\%} vs. -11.1{\%}) and insulin (-20.4{\%} vs. -10.8{\%}), HOMA Index (-39.2{\%} vs. -16.7{\%}), glycated haemoglobin (-10.4{\%} vs. -10.3{\%}), low-density lipoprotein cholesterol (-7.9{\%} vs. -8.5{\%}) and apolipoprotein B (-10.5{\%} vs. -5.6{\%}), after 6 months of treatment. Only the psyllium supplementation exerted a significant improvement on plasma triglyceride concentration (-13.3{\%}) and systolic (-3.9{\%}) and diastolic blood pressure (-2.6{\%}). No significant difference was observed regarding the standard diet group in comparison to the baseline. On the basis of our data, psyllium could be more strongly indicated for patients that have to reduce a large number of cardiovascular risk factors, while guar gum could be more rapidly efficacious in strengthening the effect of diets aimed at reducing body weight.",
keywords = "Cardiovascular risk, Hypercholesterolaemia, Hyperglycaemia, Hypertension, Hypertriglyceridaemia, Metabolic syndrome, Soluble fibres",
author = "Cicero, {Arrigo F G} and Giuseppe Derosa and Marilisa Bove and Fabrizio Imola and Claudio Borghi and Gaddi, {Antonio V.}",
year = "2010",
month = "4",
doi = "10.1007/s12349-009-0056-1",
language = "English",
volume = "3",
pages = "47--54",
journal = "Mediterranean Journal of Nutrition and Metabolism",
issn = "1973-798X",
publisher = "IOS Press",
number = "1",

}

TY - JOUR

T1 - Psyllium improves dyslipidaemia, hyperglycaemia and hypertension, while guar gum reduces body weight more rapidly in patients affected by metabolic syndrome following an AHA Step 2 diet

AU - Cicero, Arrigo F G

AU - Derosa, Giuseppe

AU - Bove, Marilisa

AU - Imola, Fabrizio

AU - Borghi, Claudio

AU - Gaddi, Antonio V.

PY - 2010/4

Y1 - 2010/4

N2 - The aim of this study was to comparatively evaluate the long-term effects of psyllium husk and guar gum supplementation on metabolic syndrome (MS) components. We randomised 141 MS patients to soluble psyllium husk powder or guar gum 3.5 g t.i.d. to be taken 20 min before the main 2 meals, or to a standard diet for a cumulative period of 6 months. Both fibres significantly improved body mass index (-7.2% vs. -6.5%), fasting plasma glucose (-27.9% vs. -11.1%) and insulin (-20.4% vs. -10.8%), HOMA Index (-39.2% vs. -16.7%), glycated haemoglobin (-10.4% vs. -10.3%), low-density lipoprotein cholesterol (-7.9% vs. -8.5%) and apolipoprotein B (-10.5% vs. -5.6%), after 6 months of treatment. Only the psyllium supplementation exerted a significant improvement on plasma triglyceride concentration (-13.3%) and systolic (-3.9%) and diastolic blood pressure (-2.6%). No significant difference was observed regarding the standard diet group in comparison to the baseline. On the basis of our data, psyllium could be more strongly indicated for patients that have to reduce a large number of cardiovascular risk factors, while guar gum could be more rapidly efficacious in strengthening the effect of diets aimed at reducing body weight.

AB - The aim of this study was to comparatively evaluate the long-term effects of psyllium husk and guar gum supplementation on metabolic syndrome (MS) components. We randomised 141 MS patients to soluble psyllium husk powder or guar gum 3.5 g t.i.d. to be taken 20 min before the main 2 meals, or to a standard diet for a cumulative period of 6 months. Both fibres significantly improved body mass index (-7.2% vs. -6.5%), fasting plasma glucose (-27.9% vs. -11.1%) and insulin (-20.4% vs. -10.8%), HOMA Index (-39.2% vs. -16.7%), glycated haemoglobin (-10.4% vs. -10.3%), low-density lipoprotein cholesterol (-7.9% vs. -8.5%) and apolipoprotein B (-10.5% vs. -5.6%), after 6 months of treatment. Only the psyllium supplementation exerted a significant improvement on plasma triglyceride concentration (-13.3%) and systolic (-3.9%) and diastolic blood pressure (-2.6%). No significant difference was observed regarding the standard diet group in comparison to the baseline. On the basis of our data, psyllium could be more strongly indicated for patients that have to reduce a large number of cardiovascular risk factors, while guar gum could be more rapidly efficacious in strengthening the effect of diets aimed at reducing body weight.

KW - Cardiovascular risk

KW - Hypercholesterolaemia

KW - Hyperglycaemia

KW - Hypertension

KW - Hypertriglyceridaemia

KW - Metabolic syndrome

KW - Soluble fibres

UR - http://www.scopus.com/inward/record.url?scp=77949918413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949918413&partnerID=8YFLogxK

U2 - 10.1007/s12349-009-0056-1

DO - 10.1007/s12349-009-0056-1

M3 - Article

VL - 3

SP - 47

EP - 54

JO - Mediterranean Journal of Nutrition and Metabolism

JF - Mediterranean Journal of Nutrition and Metabolism

SN - 1973-798X

IS - 1

ER -