PTX3, a prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans

Giuseppe Peri, Martino Introna, Domenico Corradi, Giuseppe Iacuitti, Stefano Signorini, Fausto Avanzini, Fabrizio Pizzetti, Aldo P. Maggioni, Tiziano Moccetti, Marco Metra, Livio DeiCas, Pietro Ghezzi, Jean D. Sipe, Gianpietro Re, Giorgio Olivetti, Alberto Mantovani, Roberto Latini

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Inflammation is an important component of ischemic heart disease. PTX3 is a long pentraxin whose expression is induced by cytokines in endothelial cells, mononuclear phagocytes, and myocardium. The possibility that PTX3 is altered in patients with acute myocardial infarction (AMI) has not yet been tested. Methods and Results - Blood samples were collected from 37 patients admitted to the coronary care unit (CCU) with symptoms of AMI. PTX3 plasma concentrations, as measured by ELISA, higher than the mean+2 SD of age-matched controls (2.01 ng/mL) were found in 27 patients within the first 24 hours of CCU admission. PTX3 peaked at 7.5 hours after CCU admission, and mean peak concentration was 6.94±11.26 ng/mL. Plasma concentrations of PTX3 returned to normal in all but 3 patients at hospital discharge and were unrelated to AMI site or extent, Killip class at entry, hours from symptom onset, and thrombolysis. C-reactive protein peaked in plasma at 24 hours after CCU admission, much later than PTX3 (P64 years old and women had significantly higher PTX3 concentrations at 24 hours (P

Original languageEnglish
Pages (from-to)636-641
Number of pages6
JournalCirculation
Volume102
Issue number6
Publication statusPublished - Aug 8 2000

Keywords

  • Myocardial infarction
  • Myocytes
  • Pentraxins
  • Proteins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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