PTX3 as a potential novel tool for the diagnosis and monitoring of pulmonary fungal infections in immuno-compromised pediatric patients

Ettore Biagi, Marina Col, Maddalena Migliavacca, Mariagrazia Dell'Oro, Daniela Silvestri, Alessandro Montanelli, Giuseppe Peri, Alberto Mantovani, Andrea Biondi, Mario Renato Rossi

Research output: Contribution to journalArticle

Abstract

Pentraxin-3 (PTX3) is a member of the long pentraxin superfamily and has a nonredundant role in mediating resistance to fungal pathogens. Serial monitoring of PTX3 plasmatic levels was performed in 10 pediatric leukemia patients affected by pulmonary fungal infections. When compared with values of a control pediatric cohort, PTX3 showed significantly higher plasmatic values. Moreover, the response to the antifungal therapy correlated with normalization of PTX3 values. PTX3 may represent a useful tool for the diagnosis and monitoring of fungal infections in immuno-compromised children.

Original languageEnglish
Pages (from-to)881-885
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume30
Issue number12
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Fungal infections
  • Pediatric leukemia
  • PTX3

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology
  • Medicine(all)

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